Small molecule inhibitors that target components of the spliceosome have great potential as
tools to probe splicing mechanism and dissect splicing regulatory networks in cells. These …

Alternative splicing is a key mechanism determinant for gene expression in metazoan.
During alternative splicing, non-coding sequences are removed to generate different mature …

Many oncogenic insults deregulate RNA splicing, often leading to hypersensitivity of tumors
to spliceosome-targeted therapies (STTs). However, the mechanisms by which STTs …

The eukaryotic mRNA surveillance pathway, a pivotal guardian of mRNA fidelity, stands at
the nexus of diverse biological processes, including antiviral immunity. Despite the …

Alternative pre-mRNA splicing is a tightly controlled process conducted by the spliceosome,
with the assistance of several regulators, resulting in the expression of different transcript …

Pre-mRNA splicing is a fundamental process in mammalian gene expression and
alternative RNA splicing plays a considerable role in generating protein diversity. RNA …

The fidelity of alternative splicing (AS) patterns is essential for growth development and cell
fate determination. However, the scope of the molecular switches that regulate AS remains …

RNA splicing represents a post-transcriptional mechanism to generate multiple functional
RNAs or proteins from a single transcript. The evolution of RNA splicing is a prime example …

Pre-mRNA splicing is a fundamental process that plays a considerable role in generating
protein diversity. Pre-mRNA splicing is also the key to the pathology of numerous diseases …

Abstract Purpose of Review This review aims to give an update on recent findings related to
the cardiac splicing factor RNA-binding motif protein 20 (RBM20) and RBM20 …