The excitation-inhibition (E/I) imbalance is an important molecular pathological feature of
major depressive disorder (MDD) as altered GABA and glutamate levels have been found in …

Significance: Our current knowledge of the pathophysiology and molecular mechanisms
causing psychiatric disorders is modest, but genetic susceptibility and environmental factors …

We conducted a genome-wide association study (GWAS) with replication in 36,180 Chinese
individuals and performed further transancestry meta-analyses with data from the Psychiatry …

Major depressive disorder (MDD) is a serious psychiatric disorder that associated with high
rate of disability and increasing suicide rate, and the pathogenesis is still unclear. Many …

Aberrations in neurodevelopmental trajectories have been implicated in the neurobiology of
several mental disorders and evidence indicates a pathophysiological and genetic overlap …

Psychiatric disorders represent a great medical and social challenge and people suffering
from these conditions face many impairments regarding personal and professional life. In …

Bipolar disorder (BD) is a chronic and progressive psychiatric illness characterized by mood
oscillations, with episodes of mania and depression. The impact of BD on patients can be …

Women are under-represented in research on suicidality to date. Although women have a
lower rate of suicide completion than men, due in part to the less-violent methods used, they …

Schizophrenia (SCZ) and bipolar disorder are debilitating neuropsychiatric disorders arising
from a combination of environmental and genetic factors. Novel open reading frames …

Purpose The nutritional intervention program “DiOGenes” focuses on how obesity can be
prevented and treated from a dietary perspective. We generated differential plasma …