Abstract Non-enzymatic chitinase-3 like-protein-1 (CHI3L1) belongs to glycoside hydrolase
family 18. It binds to chitin, heparin, and hyaluronic acid, and is regulated by extracellular …

Chitin is a long-chain polymer of N-acetyl-glucosamine, which is regularly found in the
exoskeleton of arthropods including insects, shellfish and the cell wall of fungi. It has been …

Asthma is a heterogenous disease characterized by multiple phenotypes driven by different
mechanisms. The implementation of precision medicine in the management of asthma …

Asthma is a chronic inflammatory disease that undermines the airways. It is caused by
dysfunction of various types of cells, as well as cellular components, and is characterized by …

Rationale: Serum chitinases may be novel biomarkers of airway inflammation and
remodeling, but less is known about factors regulating their levels. Objectives: To examine …

Background Problematic severe childhood asthma includes a subgroup of patients who are
resistant to therapy. The specific mechanisms involved are unknown, and novel biomarkers …

Assessment and management of asthma is complicated by the heterogeneous
pathophysiological mechanisms that underlie its clinical presentation, which are not …

Recently, the serum levels of YKL-40, a chitinase-like glycoprotein, have been shown to be
significantly elevated in asthmatics and are associated with asthma severity. Although these …

Airway remodeling is accepted to be a determining component within the natural history of
asthma. It is a phenomenon characterized by changes in the airways structures that marches …

Rationale: Bronchial remodeling, including increased bronchial smooth muscle (BSM) mass,
contributes to bronchial obstruction in asthma. However, its mechanisms are complex and …