Inflammation plays an important role in the pathogenesis of ischemic stroke and other forms
of ischemic brain injury. Increasing evidence suggests that inflammatory response is a …

Introduction. Human neurodegenerative diseases increase progressively with age and
present a high social and economic burden. Growth hormone (GH) and insulin-like growth …

Background and Purpose—The performance of validated prognostic clinical models in acute
ischemic stroke might be improved by addition of data on blood biomarkers. Methods—We …

Background and Purpose—The diagnosis of ischemic stroke can be difficult. CT may be
normal in the early stages of ischemic stroke or in patients with minor symptoms and MR is …

Summary Background GH and IGF‐I affect cardiac structure and performance. In the general
population, low IGF‐I has been associated with higher prevalence of ischaemic heart …

This review focuses on cardiovascular protective effects of insulin-like growth factor (IGF)-1,
provides a landscape of molecular mechanisms involved in cardiovascular alterations in …

Recent studies demonstrate that age-related dysfunction of NF-E2–related factor-2 (Nrf2)–
driven pathways impairs cellular redox homeostasis, exacerbating age-related cellular …

Recent studies confirm that dietary methionine restriction increases both mean and maximal
lifespan in rats and mice, achieving “aging retardant” effects very similar to those of caloric …

The optimal amount of endurance exercise required to elevate proteins involved in
neuroplasticity during stroke rehabilitation is not known. This study compared the effects of …

The insulin-like growth factor 1 (IGF1) signaling pathway has emerged as a major regulator
of the aging process, from rodents to humans. However, given the pleiotropic actions of …