A detailed overview of immune escape, antibody escape, partial vaccine escape of SARS-CoV-2 and their emerging variants with escape mutations
The infective SARS-CoV-2 is more prone to immune escape. Presently, the significant
variants of SARS-CoV-2 are emerging in due course of time with substantial mutations …
variants of SARS-CoV-2 are emerging in due course of time with substantial mutations …
Pathogenesis of Zika virus infection
MI Giraldo, M Gonzalez-Orozco… - Annual Review of …, 2023 - annualreviews.org
Zika virus (ZIKV) is an emerging virus from the Flaviviridae family that is transmitted to
humans by mosquito vectors and represents an important health problem. Infections in …
humans by mosquito vectors and represents an important health problem. Infections in …
An evolutionary NS1 mutation enhances Zika virus evasion of host interferon induction
Virus–host interactions determine an infection outcome. The Asian lineage of Zika virus
(ZIKV), responsible for the recent epidemics, has fixed a mutation in the NS1 gene after …
(ZIKV), responsible for the recent epidemics, has fixed a mutation in the NS1 gene after …
Recent African strains of Zika virus display higher transmissibility and fetal pathogenicity than Asian strains
The global emergence of Zika virus (ZIKV) revealed the unprecedented ability for a mosquito-
borne virus to cause congenital birth defects. A puzzling aspect of ZIKV emergence is that all …
borne virus to cause congenital birth defects. A puzzling aspect of ZIKV emergence is that all …
Zika virus elicits inflammation to evade antiviral response by cleaving cGAS via NS 1‐caspase‐1 axis
Y Zheng, Q Liu, Y Wu, L Ma, Z Zhang, T Liu, S Jin… - The EMBO …, 2018 - embopress.org
Viral infection triggers host innate immune responses, which primarily include the activation
of type I interferon (IFN) signaling and inflammasomes. Here, we report that Zika virus (ZIKV) …
of type I interferon (IFN) signaling and inflammasomes. Here, we report that Zika virus (ZIKV) …
An immunocompetent mouse model of Zika virus infection
Progress toward understanding Zika virus (ZIKV) pathogenesis is hindered by lack of
immunocompetent small animal models, in part because ZIKV fails to effectively antagonize …
immunocompetent small animal models, in part because ZIKV fails to effectively antagonize …
Type I interferons instigate fetal demise after Zika virus infection
Zika virus (ZIKV) infection during pregnancy is associated with adverse fetal outcomes,
including microcephaly, growth restriction, and fetal demise. Type I interferons (IFNs) are …
including microcephaly, growth restriction, and fetal demise. Type I interferons (IFNs) are …
Antiviral strategies targeting host factors and mechanisms obliging+ ssRNA viral pathogens
The ongoing COVID-19 pandemic, periodic recurrence of viral infections, and the
emergence of challenging variants has created an urgent need of alternative therapeutic …
emergence of challenging variants has created an urgent need of alternative therapeutic …
The influenza virus PB2 protein evades antiviral innate immunity by inhibiting JAK1/STAT signalling
H Yang, Y Dong, Y Bian, N Xu, Y Wu, F Yang… - Nature …, 2022 - nature.com
Influenza A virus (IAV) polymerase protein PB2 has been shown to partially inhibit the host
immune response by blocking the induction of interferons (IFNs). However, the IAV PB2 …
immune response by blocking the induction of interferons (IFNs). However, the IAV PB2 …
Species-specific disruption of STING-dependent antiviral cellular defenses by the Zika virus NS2B3 protease
The limited host tropism of numerous viruses causing disease in humans remains
incompletely understood. One example is Zika virus (ZIKV), an RNA virus that has …
incompletely understood. One example is Zika virus (ZIKV), an RNA virus that has …