▪ Abstract NK cells are regulated by opposing signals from receptors that activate and inhibit
effector function. While positive stimulation may be initiated by an array of co-stimulatory …

Transcription factors have a profound influence on both the differentiation and effector
function of cells of the immune system. T-bet controls the cytotoxicity of CD8+ T cells and the …

A novel polymorphism in the extracellular domain 2 (EC2) of FcgammaRIIIA affects ligand
binding by natural killer (NK) cells and monocytes from genotyped homozygous normal …

Mature natural killer (NK) cells use Ca2+-dependent granule exocytosis and release of
cytotoxic proteins, Fas ligand (FasL), and membrane-bound or secreted cytokines (tumor …

When once your point of view is changed, the very thing ADCC mediated by NK cells is
initiated by engagement which was so damning becomes a clue to the truth. of low-affinity Fc …

Spliced X-box–binding protein 1 (XBP1s) is an essential transcription factor downstream of
interleukin-15 (IL-15) and AKT signaling, which controls cell survival and effector functions of …

Abstract Background: The transmembrane receptor Fas, together with its protein-binding
partner (Fas ligand), is a key regulator of programmed cell death (ie, apoptosis). Fas and …

Objective Apoptosis of endothelial cells is a key event in the pathogenesis of systemic
sclerosis (SSc). The aim of the present study was to analyze in vitro the mechanism causing …

Throughout their development, B cells express specialised receptors with the capacity to
interact with the Fc domain of antibodies. Engagement of these Fc receptors (FcRs) …

Killer cell Ig-like receptor (KIR) 2DL4 (2DL4, CD158d) was previously described as the only
KIR expressed by every human NK cell. It is also structurally atypical among KIRs because it …