Living organisms depend on timely and organized interactions between proteins linked in
interactomes of high complexity. The recent increased precision by which protein …

Signaling pathways allow cells to detect and respond to a wide variety of chemical (eg Ca2+
or chemokine proteins) and physical stimuli (eg, sheer stress, light). Together, these …

Intrinsically disordered or unstructured proteins (or regions in proteins) have been found to
be important in a wide range of biological functions and implicated in many diseases. Due to …

Motivation Protein intrinsic disorder describes the tendency of sequence residues to not fold
into a rigid three-dimensional shape by themselves. However, some of these disordered …

Molecular recognition features (MoRFs) are short protein-binding regions that undergo
disorder-to-order transitions (induced folding) upon binding protein partners. These regions …

One of the key features of intrinsically disordered regions (IDRs) is their ability to interact
with a broad range of partner molecules. Multiple types of interacting IDRs were identified …

Machine learning (ML) has been an important arsenal in computational biology used to
elucidate protein function for decades. With the recent burgeoning of novel ML methods and …

Abstract Motivation Disordered flexible linkers (DFLs) are abundant and functionally
important intrinsically disordered regions that connect protein domains and structural …

Intrinsically disordered protein regions, IDRs, are observed in many eukaryotic proteins.
They play critical roles in essentially all cellular processes because segments of these …

Intrinsically disordered proteins and regions (IDP/IDRs) are widespread in living organisms
and perform various essential molecular functions. These functions are summarized as six …