The MYC oncoprotein functions as a master regulator of cellular transcription and executes
non-transcriptional tasks relevant to DNA replication and cell cycle regulation, thereby …

N-Myc is a key driver of neuroblastoma and neuroendocrine prostate cancer (NEPC). One
potential way to circumvent the challenge of undruggable N-Myc is to target the protein …

Abstract Background Transcription factor c-Myc plays a critical role in various physiological
and pathological events. c-Myc gene rearrangement is closely associated with multiple …

Myeloid differentiation factor 88 (MyD88) is a hub protein in the Toll-like receptor signaling
pathway, which acts as a master switch for numerous inflammatory diseases, including …

Motivation Cell-type-specific gene expression is maintained in large part by transcription
factors (TFs) selectively binding to distinct sets of sites in different cell types. Recent …

We selected the G-quadruplex motif located in the nuclease-hypersensitive elements (NHE)
III1 region of the c-Myc promoter and for the first time performed its interaction studies with a …

The Myc family of transcription factors are involved in the development and progression of
numerous cancers, including prostate cancer (PCa). Under the pressure of androgen …

Introduction The life cycle of a virus involves interacting with the host cell, entry, hijacking
host machinery for viral replication, evading the host's immune system, and releasing mature …

Protein–protein interactions drive various biological processes in healthy as well as disease
states. The transcription factor c-Myc plays a crucial role in maintaining cellular homeostasis …

This study investigated whether 10058-F4, a small molecule inhibitor of the c-Myc gene,
could play a corresponding inhibitory role in the vascular proliferation process. The efficacy …