Osteogenesis imperfecta (OI) is a heterogeneous heritable skeletal dysplasia characterized
by bone fragility and deformity, growth deficiency, and other secondary connective tissue …

Biomineralization is a highly regulated process that results in the deposition of minerals in a
precise manner, ultimately producing skeletal and dental hard tissues. Recent studies have …

Aging in mammals is accompanied by an imbalance of intestinal homeostasis and
accumulation of mitochondrial DNA (mtDNA) mutations. However, little is known about how …

Backgrounds Cutaneous T cell lymphoma (CTCL) is a non-Hodgkin lymphoma
characterized by skin infiltration of malignant T cells. The biological overlap between …

The regeneration of bone defects in diabetic patients still faces challenges, as the intrinsic
healing process is impaired by hyperglycemia. Inspired by the discovery that the …

Osteogenesis imperfecta (OI) is a rare heritable connective tissue disorder of skeletal
fragility with an incidence of roughly 1: 15,000. Approximately 85% of the pathogenic …

Osteogenesis Imperfecta (OI) is a heritable collagen-related bone dysplasia characterized
by bone fractures, growth deficiency and skeletal deformity. Type XIV OI is a recessive OI …

Qualitative alterations in type I collagen due to pathogenic variants in the COL1A1 or
COL1A2 genes, result in moderate and severe Osteogenesis Imperfecta (OI), a rare disease …

Collagenopathies are a group of clinically diverse disorders caused by defects in collagen
folding and secretion. For example, mutations in the gene encoding collagen type-II, the …

Bone histomorphometry is a well-established approach to assessing skeletal pathology,
providing a standard evaluation of the cellular components, architecture, mineralization, and …