Together with core histones, which make up the nucleosome, the linker histone (H1) is one
of the five main histone protein families present in chromatin in eukaryotic cells. H1 binds to …

Nucleosomes and chromatin control eukaryotic genome accessibility and thereby regulate
DNA processes, including transcription, replication, and repair. Conformational dynamics …

The human genome folds to create thousands of intervals, called" contact domains," that
exhibit enhanced contact frequency within themselves." Loop domains" form because of …

Whereas folding of genomes at the large scale of epigenomic compartments and
topologically associating domains (TADs) is now relatively well understood, how chromatin …

Liquid–liquid phase separation (LLPS) is an important mechanism that helps explain the
membraneless compartmentalization of the nucleus. Because chromatin compaction and …

In vivo, the human genome folds into a characteristic ensemble of 3D structures. The
mechanism driving the folding process remains unknown. We report a theoretical model for …

Inside the cell nucleus, genomes fold into organized structures that are characteristic of cell
type. Here, we show that this chromatin architecture can be predicted de novo using …

The dynamic architecture of chromatin fibers, a key determinant of genome regulation, is
poorly understood. Here, we employ multimodal single-molecule Förster resonance energy …

Nucleosomes form heterogeneous groups in vivo, named clutches. Clutches are smaller
and less dense in mouse embryonic stem cells (ESCs) compared to neural progenitor cells …

We reassess progress in the field of biomolecular modeling and simulation, following up on
our perspective published in 2011. By reviewing metrics for the field's productivity and …