A milestone in the evolutionary emergence of vertebrates was the invention of cartilage, a
tissue that has key roles in modeling, protecting and complementing the bony skeleton …

Highlights•Different OA etiologies present a challenge for developing a single targeted
therapy.•Common mechanisms occur in inflammatory, mechanical, and oxidative stress in …

Osteoarthritis (OA) is the most prevalent and debilitating joint disease, and there are
currently no effective disease-modifying treatments available. Multiple risk factors for OA …

Articular cartilage is a connective tissue lining the surfaces of synovial joints. When the
cartilage severely wears down, it leads to osteoarthritis (OA), a debilitating disease that …

Clinical efforts to repair damaged articular cartilage (AC) currently face major obstacles due
to limited intrinsic repair capacity of the tissue and unsuccessful biological interventions …

Owing to the rapid aging of society, the numbers of patients with joint disease continue to
increase. Accordingly, a large number of patients require appropriate treatment for …

Introduction Osteoarthritis (OA) is a heterogeneous and complex disease. We have used a
network biology approach based on genome-wide analysis of gene expression in OA knee …

Objective To perform a genome‐wide DNA methylation study to identify DNA methylation
changes in osteoarthritic (OA) cartilage tissue. Methods The contribution of differentially …

Objectives Analysing expression patterns of Krüppel-like factor (KLF) transcription factors in
normal and osteoarthritis (OA) human cartilage, and determining functions and mechanisms …

Osteoarthritis (OA), characterized by insufficient extracellular matrix synthesis and cartilage
degeneration, is known as an incurable disease because its pathogenesis is poorly …