Lysosomes are the main proteolytic compartments of mammalian cells comprising of a
battery of hydrolases. Lysosomes dispose and recycle extracellular or intracellular …

Background Cysteine cathepsins are normally found in the lysosomes where they are
involved in intracellular protein turnover. Their ability to degrade the components of the …

Background Odanacatib, a cathepsin K inhibitor, reduces bone resorption while maintaining
bone formation. Previous work has shown that odanacatib increases bone mineral density in …

Cysteine protease cathepsins have traditionally been considered as lysosome-restricted
proteases that mediate proteolysis of unwanted proteins. However, studies from the past …

Cathepsin B (CTSB), a lysosomal cysteine protease, plays an important role in human
physiology and pathology. CTSB is associated with various human diseases, and its …

Cysteine cathepsins are lysosomal enzymes belonging to the papain family. Their
expression is misregulated in a wide variety of tumors, and ample data prove their …

Biomedical research often focuses on properties that differentiate between diseased and
healthy tissue; one of the current focuses is elevated expression and altered localisation of …

Atherosclerotic cardiovascular disease (ASCVD) is an inflammatory disease characterized
by extensive arterial wall matrix protein degradation. Cysteine protease cathepsins play a …

Cystatin C (cys-C) is a small protein molecule (120 amino acid peptide chain, approximately
13kDa) produced by virtually all nucleated cells in the human body. It belongs to the family …

Aims We previously demonstrated that iron overload induces endothelial dysfunction and
oxidative stress, which could increase the risk for atherosclerosis. However, the iron-related …