Intervertebral disc (IVD) degeneration (IVDD) is the most common spinal disorder, which can
lead to the symptoms of neck pain or low back pain. In healthy mature IVD tissues …

A comprehensive understanding of the cellular heterogeneity and molecular mechanisms
underlying the development, homeostasis, and disease of human intervertebral disks (IVDs) …

Proteoglycans through their sulfated glycosaminoglycans regulate cell-matrix signaling
during tissue development, regeneration, and degeneration processes. Large extracellular …

Low back pain (LBP) is often associated with the degeneration of human intervertebral discs
(IVDs). However, the pain-inducing mechanism in degenerating discs remains to be …

Idiopathic scoliosis (IS) is the most common type of musculoskeletal defect affecting children
worldwide, and is classified by age of onset, location and degree of spine curvature …

Background Lubricin, a mucinous glycoprotein secreted by synoviocytes and chondrocytes
plays an important role in reducing the coefficient of friction in mammalian joints. Elevated …

Intervertebral disc degeneration, which leads to low back pain, is the most prevalent
musculoskeletal condition worldwide, significantly impairing quality of life and imposing …

Background Stem cell‐based therapies show promise as a means of repairing the
degenerate intervertebral disc, with growth factors often used alongside cells to help direct …

Disc degeneration and associated back and neck pain elicits a substantial burden on
healthcare systems and the individuals affected, necessitating the development of novel …

Objective To explore the expression of lubricin in the lumbar endplate and its association
with Modic changes (MCs). Methods Human endplate specimens harvested from patients …