Sensorineural hearing impairment is the most common sensory disorder and a major health
and socio-economic issue in industrialized countries. It is primarily due to the degeneration …

The inner ear represents one of the most technologically challenging targets for local drug
delivery, but its clinical significance is rapidly increasing. The prevalence of sensorineural …

Cochlear gene therapy holds promise for the treatment of genetic deafness. Assessing its
impact in adult murine models of hearing loss, however, has been hampered by technical …

HZSM-5 with high surface area of 625 m 2/g was successfully synthesized by hydrothermal
method at 160° C for 72 h. The metal promoted on HZSM-5 catalyst was prepared by liquid …

Age-related hearing loss (ARHL)-presbycusis-is the most prevalent neurodegenerative
disease and number one communication disorder of our aged population; and affects …

Murine models are ideal for studying cochlear gene transfer, as many hearing loss-related
mutations have been discovered and mapped within the mouse genome. However, because …

Advances in protective and restorative biotherapies have created new opportunities to use
site-directed, programmable drug delivery systems to treat auditory and vestibular disorders …

Introduction: Advances in molecular biology and in the basic understanding of the
mechanisms associated with sensorineural hearing loss and other diseases of the inner ear …

Introduction: Diseases of the inner ear include those of the auditory and vestibular systems,
and frequently result in disabling hearing loss or vertigo. Despite a rapidly expanding …

There are a variety of methods to access the inner ear and many of these methods depend
on utilizing the middle ear as a portal. In this approach the middle ear can be used as a …