Background: p53 is a tumor suppressor protein involved in regulating a wide array of
signaling pathways. The role of p53 in the cell is determined by the type of imposed …

Adult skeletal muscle possesses extraordinary regeneration capacities. After muscle injury
or exercise, large numbers of newly formed muscle fibers are generated within a week as a …

Oxygen sensing is central to metazoan biology and has implications for human disease.
Mammalian cells express multiple oxygen-dependent enzymes called 2-oxoglutarate (OG) …

Muscle differentiation is a crucial process controlling muscle development and homeostasis.
Mitochondrial reactive oxygen species (mtROS) rapidly increase and function as critical cell …

Skeletal muscle is highly developed after birth, consisting of glycolytic fast-twitch and
oxidative slow-twitch fibers; however, the mechanisms of fiber-type-specific differentiation …

The muscle satellite cell is essential for skeletal muscle regeneration. It is located on the
muscle fibre, under the basal lamina as a quiescent cell, which becomes activated after …

Microenvironmental oxygen (O2) regulates stem cell activity, and a hypoxic niche with low
oxygen levels has been reported in multiple stem cell types. Satellite cells are muscle …

Chronic obstructive pulmonary disease (COPD) is a worldwide prevalent respiratory disease
mainly caused by tobacco smoke exposure. COPD is now considered as a systemic disease …

Stem cell therapy has the potential to regenerate heart tissue damaged by myocardial
infarction (MI), but it experiences extremely low efficacy. One of the major causes is the …

Skeletal muscle wasting contributes to impaired exercise capacity, reduced health-related
quality of life and is an independent determinant of mortality in chronic obstructive …