Overweight and obesity are a worldwide public health problem. Obesity prevalence has
increased considerably, which indicates the need for more studies to better understand …

Obesity is a key risk factor for metabolic and cardiovascular diseases, and although we
understand the mechanisms regulating weight and energy balance, the causes of some …

Background Secondary lymphedema is a common complication of cancer treatment, and
previous studies have shown that the expression of transforming growth factor‐beta 1 (TGF …

Although clinical outcomes for patients with rheumatoid arthritis (RA) have greatly improved
with the use of biologic and conventional DMARDs, approximately 40% of patients do not …

Throughout life, it is necessary to adapt to the Earth's environment in order to survive. A
typical example of this is that the daily Earth cycle is different from the circadian rhythm in …

The lymphatic vasculature has traditionally been thought to play a passive role in the
regulation of immune responses by transporting antigen presenting cells and soluble …

Lymphatic vessels are the primary route of communication from peripheral tissues to the
immune system; as such, they represent an important component of local immunity. In …

Methods: We compared the effects of HFD on obesity-prone and obesity-resistant mice and
analyzed lymphatic function in vivo and in vitro. Results: Only obesity-prone mice had …

Alopecia areata is a representative inflammatory skin disease that is associated with various
environmental stimuli. While psychological stress is believed to be a major pathogenetic …

Key points Obesity induces lymphatic leakiness, decreases initial lymphatic vessel density,
impairs collecting vessel pumping and decreases transport of macromolecules. Obesity …