Fluoroquinolones: blessings or curses

PP Majalekar, PJ Shirote - Current Drug Targets, 2020 - ingentaconnect.com
Fluoroquinolones are one of the world's most valuable and popularly used categories of
antimicrobial agents. This paper attempts to review the substantial progress of …

The potential role of Fluoroquinolones in the management of Covid-19 a rapid review

ZA Damanhouri, HM Alkreathy, AS Ali… - Journal of Advanced …, 2021 - japer.in
COVID-19 is a pandemic viral pneumonia caused by β-coronavirus SARS-CoV-2. It is
associated with many complications including extreme systemic inflammatory response …

Antitussive noscapine and antiviral drug conjugates as arsenal against COVID-19: a comprehensive chemoinformatics analysis

N Kumar, A Awasthi, A Kumari, D Sood… - Journal of …, 2022 - Taylor & Francis
Coronavirus pandemic has caused a vast number of deaths worldwide. Thus creating an
urgent need to develop effective counteragents against novel coronavirus disease (COVID …

Evaluation of flavonoids as 2019-nCoV cell entry inhibitor through molecular docking and pharmacological analysis

D Bhowmik, R Nandi, A Prakash, D Kumar - Heliyon, 2021 - cell.com
Abstract The outbreak of Coronavirus Disease 2019 (COVID-19) has been declared as a
Public Health Emergency of International Concern (PHEIC) by the World Health …

Molecular binding mechanism and pharmacology comparative analysis of noscapine for repurposing against SARS-CoV-2 protease

N Kumar, D Sood, PJ van Der Spek… - Journal of Proteome …, 2020 - ACS Publications
Originating in the city of Wuhan in China in December 2019, COVID-19 has emerged now
as a global health emergency with a high number of deaths worldwide. COVID-19 is caused …

QSAR, simulation techniques, and ADMET/pharmacokinetics assessment of a set of compounds that target MAO-B as anti-Alzheimer agent

A Ajala, A Uzairu, GA Shallangwa… - Future Journal of …, 2023 - Springer
Background Alzheimer's disease (AD), the most common cause of dementia in the elderly, is
a progressive neurodegenerative disorder that gradually affects cognitive function and …

Quinolones as prospective drugs: Their syntheses and biological applications

AA Aly, M Ramadan, GEDA Abuo-Rahma… - Advances in heterocyclic …, 2021 - Elsevier
Quinolones continue to receive significant attention owing to their diverse range of biological
activities. They provide an important scaffold in anticancer, antibacterial and antiviral drug …

Mechanistic interaction of triflate based noscapine ionic liquid with BSA: Spectroscopic and chemoinformatics approaches

H Sehrawat, N Kumar, D Sood, L Kumar… - Journal of Molecular …, 2020 - Elsevier
In the present era, Ionic liquids (ILs) are showing great importance in many fields of
research. Apart from those applications, researchers have grown their interest in …

Privileged scaffold chalcone: synthesis, characterization and its mechanistic interaction studies with BSA employing spectroscopic and chemoinformatics approaches

N Singh, N Kumar, G Rathee, D Sood, A Singh… - ACS …, 2020 - ACS Publications
Chalcone, a privileged structure, is considered as an effective template in the field of
medicinal chemistry for potent drug discovery. In the present study, a privileged template …

Deciphering the binding mechanism of noscapine with lysozyme: biophysical and chemoinformatic approaches

D Sood, N Kumar, A Singh, V Tomar, SK Dass… - ACS …, 2019 - ACS Publications
Lysozyme is a well-characterized protein in terms of its structure, dynamics, and functions. It
has thus emerged as a potential target to understand protein–drug interactions. The aim of …