Next generation of immune checkpoint inhibitors and beyond
JA Marin-Acevedo, EMO Kimbrough, Y Lou - Journal of hematology & …, 2021 - Springer
The immune system is the core defense against cancer development and progression.
Failure of the immune system to recognize and eliminate malignant cells plays an important …
Failure of the immune system to recognize and eliminate malignant cells plays an important …
Dynamic polarization of tumor-associated macrophages and their interaction with intratumoral T cells in an inflamed tumor microenvironment: from mechanistic …
J Han, L Dong, M Wu, F Ma - Frontiers in Immunology, 2023 - frontiersin.org
Immunotherapy has brought a paradigm shift in the treatment of tumors in recent decades.
However, a significant proportion of patients remain unresponsive, largely due to the …
However, a significant proportion of patients remain unresponsive, largely due to the …
Systemic blockade of clever-1 elicits lymphocyte activation alongside checkpoint molecule downregulation in patients with solid tumors: results from a phase I/II …
R Virtakoivu, JH Rannikko, M Viitala, F Vaura… - Clinical Cancer …, 2021 - AACR
Purpose: Macrophages are critical in driving an immunosuppressive tumor
microenvironment that counteracts the efficacy of T-cell–targeting therapies. Thus, agents …
microenvironment that counteracts the efficacy of T-cell–targeting therapies. Thus, agents …
Metabolic regulation of tumor-associated macrophage heterogeneity: insights into the tumor microenvironment and immunotherapeutic opportunities
Y Qian, Y Yin, X Zheng, Z Liu, X Wang - Biomarker Research, 2024 - Springer
Tumor-associated macrophages (TAMs) are a heterogeneous population that play diverse
functions in tumors. Their identity is determined not only by intrinsic factors, such as origins …
functions in tumors. Their identity is determined not only by intrinsic factors, such as origins …
An update on the use of immunotherapy in patients with colorectal cancer
M Nguyen, S Tipping Smith, M Lam, E Liow… - Expert review of …, 2021 - Taylor & Francis
Introduction: Colorectal cancer (CRC) is the third most common malignancy worldwide, with
recent trends demonstrating increasing incidence amongst younger patients. Despite …
recent trends demonstrating increasing incidence amongst younger patients. Despite …
Nonclinical characterization of bexmarilimab, a clever-1–targeting antibody for supporting immune defense against cancers
M Hollmén, M Maksimow, JH Rannikko… - Molecular Cancer …, 2022 - AACR
Common lymphatic endothelial and vascular endothelial receptor-1 (Clever-1) is a
multifunctional type-1 transmembrane protein that plays an important role in …
multifunctional type-1 transmembrane protein that plays an important role in …
Stage I–IV Colorectal Cancer Prognosis Can Be Predicted by Type and Number of Intratumoral Macrophages and CLEVER-1+ Vessel Density
A Ålgars, L Kemppinen, R Fair-Mäkelä, H Mustonen… - Cancers, 2021 - mdpi.com
Simple Summary Tumor-associated macrophages can either promote or prevent cancer
growth depending on factors such as macrophage polarization status, tumor type, and …
growth depending on factors such as macrophage polarization status, tumor type, and …