Background Recent advances in genomewide studies have revealed the abundance of long
non-coding RNAs (lncRNAs) in mammalian transcriptomes. The ENCODE Consortium has …

Central nervous system (CNS) development, homeostasis, stress responses, and plasticity
are all mediated by epigenetic mechanisms that modulate gene expression and promote …

Background To date, there are no highly sensitive and specific minimally invasive
biomarkers for detection of breast cancer at an early stage. The occurrence of circulating …

Background There is no standard serum biomarker used for diagnosis or early detection of
recurrence for renal cell carcinoma (RCC) patients. MicroRNAs (miRNAs) are abundant and …

Early cancer detection and disease stratification or classification are critical to successful
treatment. Accessible, reliable, and informative cancer biomarkers can be medically …

Infertility is a common problem affecting one in six couples and in 30% of infertile couples,
the male factor is a major cause. A large number of genes are involved in spermatogenesis …

The number of reported germline mutations in human nuclear genes, either underlying or
associated with inherited disease, has now exceeded 100,000 in more than 3,700 different …

BACKGROUND Achieving the correct spatial and temporal expression of germ-cell-specific
genes is fundamental to the production of viable healthy spermatozoa. Notably, post …

Objective To compare the microRNA (miRNA) expression profile in spermatozoa from three
infertile populations vs. a group of fertile men. Design Evaluation of the expression level of …

Background MicroRNAs (miRNAs) are a class of noncoding small RNAs that play important
roles in many physiological processes by regulating gene expression. Previous studies …