Brain metastases present a significant public health issue, affecting more than 100,000
patients per year in the US and result in significant morbidity. Brain metastases can occur in …

Because of improved survival of cancer patients, more patients irradiated for brain
metastases develop intracerebral recurrences requiring subsequent courses of …

Objectives Patients with brain metastases from small-cell lung cancer (SCLC) who
underwent prior prophylactic cranial irradiation (PCI) are often treated with a second course …

Simple Summary Some institutions consider re-whole brain radiotherapy (WBRT)
administration for brain metastases recurrence; however, there is insufficient information …

Brain metastases are a common, and frequently challenging, clinical problem in the
contemporary management of metastatic breast cancer. While the management of …

Purpose Whole brain radiation therapy (WBRT) remains the standard of care for patients
with multiple brain metastases, but more than half of treated patients will develop intracranial …

A second course of whole brain radiation therapy (WBRT) has been employed in selected
patients with progressive brain metastases providing favorable symptomatic palliation with …

Background Small cell lung cancer (SCLC) can recur in the brain after whole-brain
irradiation (WBI). We documented outcomes after treatment of such recurrences and sought …

Background Patients with multiple brain metastases are often treated with whole brain
radiation therapy (WBRT). Second course of WBRT is an important treatment option for …

Due to advances in the systemic and local treatment, eg, targeted therapy, immune
checkpoint inhibitors, and stereotactic radiotherapy, an increasing proportion of patients with …