Engineering mesoporous silica nanoparticles for drug delivery: where are we after two decades?
The present review details a chronological description of the events that took place during
the development of mesoporous materials, their different synthetic routes and their use as …
the development of mesoporous materials, their different synthetic routes and their use as …
A historical review of brain drug delivery
WM Pardridge - Pharmaceutics, 2022 - mdpi.com
The history of brain drug delivery is reviewed beginning with the first demonstration, in 1914,
that a drug for syphilis, salvarsan, did not enter the brain, due to the presence of a blood …
that a drug for syphilis, salvarsan, did not enter the brain, due to the presence of a blood …
Form follows function: nanoparticle shape and its implications for nanomedicine
This review is a comprehensive description of the past decade of research into
understanding how the geometry and size of nanoparticles affect their interaction with …
understanding how the geometry and size of nanoparticles affect their interaction with …
Targeting the transferrin receptor for brain drug delivery
Obtaining efficient drug delivery to the brain remains the biggest challenge for the
development of therapeutics to treat diseases of the central nervous system. The main …
development of therapeutics to treat diseases of the central nervous system. The main …
Blood-brain delivery methods using nanotechnology
Pathologies of the brain, of which brain cancer, Alzheimer's disease, Parkinson's disease,
stroke, and multiple sclerosis, are some of the most prevalent, and that presently are poorly …
stroke, and multiple sclerosis, are some of the most prevalent, and that presently are poorly …
Engineering the drug carrier biointerface to overcome biological barriers to drug delivery
Micro and nanoscale drug carriers must navigate through a plethora of dynamic biological
systems prior to reaching their tissue or disease targets. The biological obstacles to drug …
systems prior to reaching their tissue or disease targets. The biological obstacles to drug …
[HTML][HTML] Efficient delivery of Temozolomide using ultrasmall large-pore silica nanoparticles for glioblastoma
The prognosis of brain cancers such as glioblastoma remains poor despite numerous
advancements in the field of neuro-oncology. The presence of the blood brain barrier (BBB) …
advancements in the field of neuro-oncology. The presence of the blood brain barrier (BBB) …
Nanobiotechnology-assisted therapies to manage brain cancer in personalized manner
There are numerous investigated factors that limit brain cancer treatment efficacy such as
ability of prescribed therapy to cross the blood-brain barrier (BBB), tumor specific delivery of …
ability of prescribed therapy to cross the blood-brain barrier (BBB), tumor specific delivery of …
Enhancing Methotrexate Delivery in the Brain by Mesoporous Silica Nanoparticles Functionalized with Cell-Penetrating Peptide using in Vivo and ex Vivo Monitoring
The blood–brain barrier (BBB) acts as a physical/biochemical barrier that protects brain
parenchyma from potential hazards exerted by different xenobiotics found in the systemic …
parenchyma from potential hazards exerted by different xenobiotics found in the systemic …
Nanoformulation properties, characterization, and behavior in complex biological matrices: Challenges and opportunities for brain-targeted drug delivery applications …
V Agrahari, PA Burnouf, T Burnouf… - Advanced Drug Delivery …, 2019 - Elsevier
Nanocarriers (synthetic/cell-based have attracted enormous interest for various therapeutic
indications, including neurodegenerative disorders. A broader understanding of the impact …
indications, including neurodegenerative disorders. A broader understanding of the impact …