RNA Interference (RNAi) Screening in Drosophila
In the last decade, RNA interference (RNAi), a cellular mechanism that uses RNA-guided
degradation of messenger RNA transcripts, has had an important impact on identifying and …
degradation of messenger RNA transcripts, has had an important impact on identifying and …
Big data in chemical toxicity research: the use of high-throughput screening assays to identify potential toxicants
High-throughput screening (HTS) assays that measure the in vitro toxicity of environmental
compounds have been widely applied as an alternative to in vivo animal tests of chemical …
compounds have been widely applied as an alternative to in vivo animal tests of chemical …
JAK–STAT Signaling in Inflammatory Breast Cancer Enables Chemotherapy-Resistant Cell States
Inflammatory breast cancer (IBC) is a difficult-to-treat disease with poor clinical outcomes
due to high risk of metastasis and resistance to treatment. In breast cancer, CD44+ CD24 …
due to high risk of metastasis and resistance to treatment. In breast cancer, CD44+ CD24 …
Immune Escape in Breast Cancer During In Situ to Invasive Carcinoma Transition
To investigate immune escape during breast tumor progression, we analyzed the
composition of leukocytes in normal breast tissues, ductal carcinoma in situ (DCIS), and …
composition of leukocytes in normal breast tissues, ductal carcinoma in situ (DCIS), and …
Analysis of transcriptional variability in a large human iPSC library reveals genetic and non-genetic determinants of heterogeneity
Variability in induced pluripotent stem cell (iPSC) lines remains a concern for disease
modeling and regenerative medicine. We have used RNA-sequencing analysis and linear …
modeling and regenerative medicine. We have used RNA-sequencing analysis and linear …
Defining super-enhancer landscape in triple-negative breast cancer by multiomic profiling
Breast cancer is a heterogeneous disease, affecting over 3.5 million women worldwide, yet
the functional role of cis-regulatory elements including super-enhancers in different breast …
the functional role of cis-regulatory elements including super-enhancers in different breast …
Downregulation of exhausted cytotoxic T cells in gene expression networks of multisystem inflammatory syndrome in children
Multisystem inflammatory syndrome in children (MIS-C) presents with fever, inflammation
and pathology of multiple organs in individuals under 21 years of age in the weeks following …
and pathology of multiple organs in individuals under 21 years of age in the weeks following …
LncRNA MIR200CHG inhibits EMT in gastric cancer by stabilizing miR-200c from target-directed miRNA degradation
Y Zhu, C Huang, C Zhang, Y Zhou, E Zhao… - Nature …, 2023 - nature.com
Gastric cancer (GC) is a heterogeneous disease, threatening millions of lives worldwide, yet
the functional roles of long non-coding RNAs (lncRNAs) in different GC subtypes remain …
the functional roles of long non-coding RNAs (lncRNAs) in different GC subtypes remain …
A recurrent 11q aberration pattern characterizes a subset of MYC-negative high-grade B-cell lymphomas resembling Burkitt lymphoma
I Salaverria, I Martin-Guerrero… - Blood, The Journal …, 2014 - ashpublications.org
The genetic hallmark of Burkitt lymphoma (BL) is the t (8; 14)(q24; q32) and its variants
leading to activation of the MYC oncogene. It is a matter of debate whether true BL without …
leading to activation of the MYC oncogene. It is a matter of debate whether true BL without …
siPools: highly complex but accurately defined siRNA pools eliminate off-target effects
M Hannus, M Beitzinger, JC Engelmann… - Nucleic acids …, 2014 - academic.oup.com
Short interfering RNAs (siRNAs) are widely used as tool for gene inactivation in basic
research and therapeutic applications. One of the major shortcomings of siRNA experiments …
research and therapeutic applications. One of the major shortcomings of siRNA experiments …