The slow death of the concept of schizophrenia and the painful birth of the psychosis spectrum
S Guloksuz, J van Os - Psychological medicine, 2018 - cambridge.org
The concept of schizophrenia only covers the 30% poor outcome fraction of a much broader
multidimensional psychotic syndrome, yet paradoxically has become the dominant prism …
multidimensional psychotic syndrome, yet paradoxically has become the dominant prism …
Remission and recovery from first-episode psychosis in adults: systematic review and meta-analysis of long-term outcome studies
BackgroundRemission and recovery rates for people with first-episode psychosis (FEP)
remain uncertain. AimsTo assess pooled prevalence rates of remission and recovery in FEP …
remain uncertain. AimsTo assess pooled prevalence rates of remission and recovery in FEP …
[HTML][HTML] Cognitive dysfunction in schizophrenia: an expert group paper on the current state of the art
Cognitive impairment in schizophrenia represents one of the main obstacles to clinical and
functional recovery. This expert group paper brings together experts in schizophrenia …
functional recovery. This expert group paper brings together experts in schizophrenia …
Schizophrenia: an integrated sociodevelopmental-cognitive model
OD Howes, RM Murray - The Lancet, 2014 - thelancet.com
Schizophrenia remains a major burden on patients and society. The dopamine hypothesis
attempts to explain the pathogenic mechanisms of the disorder, and the …
attempts to explain the pathogenic mechanisms of the disorder, and the …
30 years on: how the neurodevelopmental hypothesis of schizophrenia morphed into the developmental risk factor model of psychosis
At its re-birth 30 years ago, the neurodevelopment hypothesis of schizophrenia focussed on
aberrant genes and early neural hazards, but then it grew to include ideas concerning …
aberrant genes and early neural hazards, but then it grew to include ideas concerning …
The blood–brain barrier in psychosis
Blood–brain barrier pathology is recognised as a central factor in the development of many
neurological disorders, but much less is known about the role of the blood–brain barrier in …
neurological disorders, but much less is known about the role of the blood–brain barrier in …
Meta-analysis of cognitive deficits in ultra-high risk to psychosis and first-episode psychosis: do the cognitive deficits progress over, or after, the onset of psychosis?
Cognitive dysfunction is a well-established feature of schizophrenia, and there is evidence
suggesting that cognitive deficits are secondary to abnormal neurodevelopment leading to …
suggesting that cognitive deficits are secondary to abnormal neurodevelopment leading to …
The nature of relapse in schizophrenia
Background Multiple relapses characterise the course of illness in most patients with
schizophrenia, yet the nature of these episodes has not been extensively researched and …
schizophrenia, yet the nature of these episodes has not been extensively researched and …
Should psychiatrists be more cautious about the long-term prophylactic use of antipsychotics?
Patients who recover from an acute episode of psychosis are frequently prescribed
prophylactic antipsychotics for many years, especially if they are diagnosed as having …
prophylactic antipsychotics for many years, especially if they are diagnosed as having …
Structural brain changes in schizophrenia at different stages of the illness: a selective review of longitudinal magnetic resonance imaging studies
B Dietsche, T Kircher… - Australian & New Zealand …, 2017 - journals.sagepub.com
Objective: Schizophrenia is a devastating mental disorder accompanied by aberrant
structural brain connectivity. The question whether schizophrenia is a progressive brain …
structural brain connectivity. The question whether schizophrenia is a progressive brain …