Radical radiotherapy plays a major role in the treatment of non-small cell lung cancer
(NSCLC) due to the fact that many patients are medically or surgically inoperable. Advances …

Purpose Normal tissue (NT) sparing by ultra‐high dose rate (UHDR) irradiations compared
to conventional dose rate (CONV) irradiations while being isotoxic to the tumor has been …

We analyze the effect of tumor repopulation on optimal dose delivery in radiation therapy.
We are primarily motivated by accelerated tumor repopulation toward the end of radiation …

The goal in radiotherapy is to maximize the biological effect (BE) of radiation on the tumour
while limiting its toxic effects on healthy anatomies. Treatment is administered over several …

Purpose Treatment of fast-growing, human papillomavirus–negative, head and neck
cancers (HNCs) remains challenging from the perspectives of both tumor control and late …

This book explores outcome modeling in cancer from a data-centric perspective to enable a
better understanding of complex treatment response, to guide the design of advanced …

Glioblastomas are the most aggressive primary brain tumor. Despite treatment with surgery,
radiation and chemotherapy, these tumors remain uncurable and few significant increases …

Purpose: Nonuniform spatiotemporal radiotherapy fractionation schemes, ie, delivering
distinct dose distributions in different fractions can potentially improve the therapeutic ratio …

Currently, radiotherapy treatment plan acceptance is based primarily on dosimetric
performance measures. However, use of radiobiological analysis to assess benefit in terms …

In this work we review past articles that have mathematically studied cancer heterogeneity
and the impact of this heterogeneity on the structure of optimal therapy. We look at past …