The success of checkpoint blockade therapy revolutionized cancer treatment. However, we
need to increase the fraction of responding patients and overcome acquired resistance to …

Herpes simplex virus (HSV) infections of humans were first documented in ancient Greece.
Greek scholars, particularly Hippocrates, used the word" herpes," meaning to creep or crawl …

Most vertebrates are infected with one or more herpesviruses and remain so for the rest of
their lives. The relationship of immunocompetent healthy host with herpesviruses may …

Herpes simplex viruses are evolutionarily ancient and ubiquitous. In the past 20 years, there
has been increasing recognition of a worldwide pandemic of HSV-2 infection. Moreover …

This review discusses situations when the magnitude and function of immune responses to
virus infection are influenced by regulatory T cells (Tregs). The focus is on CD4+ CD25+ …

Primary infection with herpes simplex virus 1 (HSV-1) and varicella zoster virus (VZV) results
in lifelong latent infections of neurons in sensory ganglia such as the trigeminal ganglia …

During murine cytomegalovirus (mCMV) latency in the lungs, most of the viral genomes are
transcriptionally silent at the major immediate-early locus, but rare and stochastic episodes …

Immune responses must be tightly regulated to avoid hyporesponsiveness on one hand or
excessive inflammation and the development of autoimmunity (hyperresponsiveness) on the …

Abstract Live, attenuated Oka/Merck varicella-zoster virus (VZV) vaccine (zoster vaccine)
protects immunocompetent adults from herpes zoster and its complications. Success of …

The mechanism of mesenchymal stem cell therapy in acute kidney injury remains uncertain.
Previous studies indicated that mesenchymal stem cells could attenuate inflammation …