Biophysical cues, such as mechanical properties, play a critical role in tissue growth and
homeostasis. During organ development and tissue injury repair, compressive and tensional …

Two decades of studies in multiple model organisms have established the Hippo pathway
as a key regulator of organ size and tissue homeostasis. By inhibiting YAP and TAZ …

Angiogenesis is a highly coordinated process of formation of new blood vessels from pre-
existing blood vessels. The process of development of the proper vascular network is a …

Signalling from the extracellular matrix (ECM) is a fundamental cellular input that sustains
proliferation, opposes cell death and regulates differentiation. Through integrins, cells …

The Hippo pathway was initially identified in Drosophila melanogaster screens for tissue
growth two decades ago and has been a subject extensively studied in both Drosophila and …

Yes-associated protein (YAP) is regulated by mechanical cues via the interaction of the
Hippo pathway with cytoskeleton. Previous studies showed that YAP plays a role in …

YAP and TAZ are ubiquitously expressed homologous proteins originally identified as
penultimate effectors of the Hippo signaling pathway, which plays a key role in maintaining …

The mammalian MST kinase family, which is related to the Hippo kinase in Drosophila
melanogaster, includes five related proteins: MST1 (also called STK4), MST2 (also called …

The Hippo signaling network integrates diverse upstream signals to control cell fate
decisions and regulate organ growth. Recent studies have provided new insights into the …

In his classic book On Growth and Form, D'Arcy Thompson discussed the necessity of a
physical and mathematical approach to understanding the relationship between growth and …