Benzodiazepines in Alzheimer's disease: beneficial or detrimental effects

HM Al-Kuraishy, AI Al-Gareeb, HM Saad… - …, 2023 - Springer
Dementia is considered a clinical syndrome characterized by cognitive dysfunction and
memory loss. Alzheimer's disease (AD) is the most common type of dementia. AD is linked …

Insights on benzodiazepines' potential in Alzheimer's disease

HM Al-Kuraishy, AI Al-Gareeb, AA Alsayegh… - Life Sciences, 2023 - Elsevier
Alzheimer's disease (AD) is the most frequent type of dementia characterized by the
deposition of amyloid beta (Aβ) plaque and tau-neurofibrillary tangles (TNTs) in the brain …

Designer benzodiazepines: another class of new psychoactive substances

B Moosmann, V Auwärter - New Psychoactive Substances: Pharmacology …, 2018 - Springer
Benzodiazepines have been introduced as medical drugs in the 1960s. They replaced the
more toxic barbiturates, which were commonly used for treatment of anxiety or sleep …

'New/Designer Benzodiazepines': an analysis of the literature and psychonauts' trip reports

L Orsolini, JM Corkery, S Chiappini… - Current …, 2020 - ingentaconnect.com
Background: NPS belonging to the benzodiazepine (BZD) class, eg,'legal/designer
BZDs'/'research chemicals', have recently emerged in the drug (mainly online/virtual) market …

New benzodiazepines for sedation

EM Cornett, MB Novitch, AJ Brunk, KS Davidson… - Best Practice & …, 2018 - Elsevier
There are currently new drugs being developed that have benzodiazepine properties. This
review will examine remimazolam, 3-hydroxyphenazapam, adinazolam, clonazolam, and …

The evolution toward designer benzodiazepines in drug-facilitated sexual assault cases

M Pérez Orts, A van Asten… - Journal of Analytical …, 2023 - academic.oup.com
Drug-facilitated sexual assault (DFSA) is a crime where the victim is unable to provide
sexual consent due to incapacitation resulting from alcohol or drug consumption. Due to the …

A systematic study of the in vitro pharmacokinetics and estimated human in vivo clearance of indole and indazole-3-carboxamide synthetic cannabinoid receptor …

AM Brandon, LH Antonides, J Riley, O Epemolu… - Molecules, 2021 - mdpi.com
In vitro pharmacokinetic studies were conducted on enantiomer pairs of twelve valinate or
tert-leucinate indole and indazole-3-carboxamide synthetic cannabinoid receptor agonists …

A new version of the tissue composition-based model for improving the mechanism-based prediction of volume of distribution at steady-state for neutral drugs

P Poulin, JM Nicolas, F Bouzom - Journal of Pharmaceutical Sciences, 2024 - Elsevier
In-vitro models are available in the literature for predicting the volume of distribution at
steady-state (Vd ss) of drugs. The mechanistic model refers to the tissue composition-based …

Potential neonatal toxicity of new psychoactive substances

R Fujiwara, M Journey, F Al-Doori, P Bell… - Pharmacology & …, 2023 - Elsevier
Abstract Cannabis, cocaine, 3, 4-methylenedioxymethamphetamine, and lysergic acid
diethylamide are psychoactive substances with a significant increase in consumption during …

Absorption and translocation of selected pharmaceuticals in Pistia stratiotes: Spatial distribution analysis using matrix-assisted laser desorption/ionization time-of-flight …

J Wang, Y Zhu, B Ye, J Dun, X Yu, Q Sui - Journal of Hazardous Materials, 2024 - Elsevier
Phytoremediation can eliminate pharmaceuticals from aquatic environments through
absorption; however, understanding of absorption and transport processes in plants remains …