Urothelial carcinoma of the bladder is unique among epithelial carcinomas in its divergent
pathways of tumorigenesis. Low-grade papillary tumours rarely become muscle-invasive …

High recurrence rates and poor survival rates of metastatic bladder cancer emphasize the
need for a drug that can prevent and/or treat bladder cancer progression and metastasis …

The principal problem arising from prostate cancer (PCa) is its propensity to metastasize to
bone. MicroRNAs (miRNAs) play a crucial role in many tumor metastases. The importance of …

Casticin, a polymethoxyflavone derived from natural plants, has biological activities
including induction of cell apoptosis. In this study, we showed the beneficial effects of …

Abstract The phosphatidylinositol 3-kinase (PI3K) pathway is a critical signal transduction
pathway that regulates multiple cellular functions. Aberrant activation of this pathway has …

Purpose: Epithelial to mesenchymal transition (EMT) is reportedly an important transition in
cancer progression in which the underlying cellular changes have been identified mainly …

Atherosclerosis is the underlying pathology of many cardiovascular diseases. The formation
and rupture of atherosclerotic plaques in the coronary arteries results in angina and …

PURPOSE: Progression to or presentation with muscle invasive disease represents the
critical clinical step in bladder cancer, necessitating more aggressive therapy and carrying a …

Motivation: Eukaryotic gene expression (GE) is subjected to precisely coordinated multi-
layer controls, across the levels of epigenetic, transcriptional and post-transcriptional …

Cancer and embryonic stem cells exhibit similar behavior, including immortal,
undifferentiated, and invasive activities. Here, we show that in clinical samples bladder …