Early studies by Krebs (1935) suggested that glutamate played a central metabolic role in
brain. The complex compartmentation of glutamate metabolism in brain was first noted by …

Large amounts of energy are required to maintain the signaling activities of CNS cells.
Because of the fine-grained heterogeneity of brain and the rapid changes in energy …

Thirty chapters provide a handbook-like treatment of magnesium and its function in the
environment, its bioinorganic chemistry, its role for plants and in animal and human nutrition …

Abstract Adenosine A 2A receptors (A 2A R) overfunction causes synaptic and memory
dysfunction in early Alzheimer's disease (AD). In a β-amyloid (Aβ 1-42)-based model of early …

Voltage-sensitive Ca2+ channels that control neurotransmitter release are blocked by o-
conotoxin(o-CgTx) GVIA from the marine snail Conus geographus, the most widely used …

Calcium ions serve as a signal for numerous neuronal functions. This requires a very low,
modulated, resting cytosolic free Cd'concentration, and diverse mechan-isms to regulate the …

Sodium-dependent neurotransmitter transport has been studied initially in relatively intact
preparation^^-^ such as brain slices or synaptosomes. The latter are pinched-off terminals …

Many aspects of calcium homeostasis change with aging. Numerous calcium compartments
complicate studies of altered calcium regulation. However, age-related decreases in calcium …

Phenytoin is a major anticonvulsant drug that is very effective in controlling a wide variety of
seizure disorders while impairing neurological function little, if at all. Early work suggested …

Neurons process and transmit information in the form of electrical signals. Their electrical
excitability is due to the presence of voltage-sensitive ion channels in the neuronal plasma …