CD4 T helper cell subsets and related human immunological disorders
The immune system plays a critical role in protecting hosts from the invasion of organisms.
CD4 T cells, as a key component of the immune system, are central in orchestrating adaptive …
CD4 T cells, as a key component of the immune system, are central in orchestrating adaptive …
ZBTB transcription factors: key regulators of the development, differentiation and effector function of T cells
ZY Cheng, TT He, XM Gao, Y Zhao, J Wang - Frontiers in Immunology, 2021 - frontiersin.org
The development and differentiation of T cells represents a long and highly coordinated, yet
flexible at some points, pathway, along which the sequential and dynamic expressions of …
flexible at some points, pathway, along which the sequential and dynamic expressions of …
Foxp3+ T Regulatory Cells: Still Many Unanswered Questions—A Perspective After 20 Years of Study
EM Shevach - Frontiers in immunology, 2018 - frontiersin.org
T regulatory (Treg) cells were discovered more than 20 years ago and have remained a
topic of intense investigation by immunologists. The initial doubts about their existence were …
topic of intense investigation by immunologists. The initial doubts about their existence were …
4-1BBL–containing leukemic extracellular vesicles promote immunosuppressive effector regulatory T cells
J Swatler, L Turos-Korgul… - Blood …, 2022 - ashpublications.org
Chronic and acute myeloid leukemia evade immune system surveillance and induce
immunosuppression by expanding proleukemic Foxp3+ regulatory T cells (Tregs). High …
immunosuppression by expanding proleukemic Foxp3+ regulatory T cells (Tregs). High …
Emerging role of ZBTB7A as an oncogenic driver and transcriptional repressor
S Gupta, AK Singh, KS Prajapati, PP Kushwaha… - Cancer letters, 2020 - Elsevier
ZBTB7A is a member of the POK family of transcription factors that possesses a POZ-domain
at the N-terminus and Krüppel-like zinc-finger at the c-terminus. ZBTB7A was initially …
at the N-terminus and Krüppel-like zinc-finger at the c-terminus. ZBTB7A was initially …
T cell development: old tales retold by single-cell RNA sequencing
Mammalian T cell development initiates from the migration of hematopoietic progenitors to
the thymus, which undergo cell proliferation, T-lineage specification and commitment, as …
the thymus, which undergo cell proliferation, T-lineage specification and commitment, as …
Essential role of a ThPOK autoregulatory loop in the maintenance of mature CD4+ T cell identity and function
The transcription factor ThPOK (encoded by the Zbtb7b gene) controls homeostasis and
differentiation of mature helper T cells, while opposing their differentiation to CD4+ …
differentiation of mature helper T cells, while opposing their differentiation to CD4+ …
The multi-faceted functioning portrait of LRF/ZBTB7A
C Constantinou, M Spella, V Chondrou, GP Patrinos… - Human genomics, 2019 - Springer
Transcription factors (TFs) consisting of zinc fingers combined with BTB (for broad-complex,
tram-track, and bric-a-brac) domain (ZBTB) are a highly conserved protein family that …
tram-track, and bric-a-brac) domain (ZBTB) are a highly conserved protein family that …
Stepwise chromatin and transcriptional acquisition of an intraepithelial lymphocyte program
M London, AM Bilate, TBR Castro, T Sujino… - Nature …, 2021 - nature.com
Mesenteric lymph node (mLN) T cells undergo tissue adaptation upon migrating to intestinal
lamina propria and epithelium, ensuring appropriate balance between tolerance and …
lamina propria and epithelium, ensuring appropriate balance between tolerance and …
Zfp281 and Zfp148 control CD4+ T cell thymic development and TH2 functions
How CD4+ lineage gene expression is initiated in differentiating thymocytes remains poorly
understood. Here, we show that the paralog transcription factors Zfp281 and Zfp148 control …
understood. Here, we show that the paralog transcription factors Zfp281 and Zfp148 control …