The extracellular calcium receptor (CaR) is a G protein-coupled receptor (GPCR) and the
pivotal molecule regulating systemic Ca 2+ homeostasis. The CaR was a challenging target …

G protein-coupled receptors (GPCRs) are the largest human membrane protein family that
transduce extracellular signals into cellular responses. They are major pharmacological …

Аннотация Проведены анализ и систематизация субстратов семейств цитохрома P-
450, в результате которых выделены и сведены в базу данных группы субстратов с …

Introduction. CYP2D6 is a liver enzyme that metabolizes more that 25% of drugs and thus
may play a pivotal role in drug-drug interactions. The promoter sequences of cytochrome …

Methods The genotype, phenotype, and mRNA-expression in PBLs were evaluated in 124
healthy Caucasian volunteers (males and females, age range 23-59 years) on three …

Duplication of the CYP2D6 allele results in excess enzyme activity and can alter the effects
of administered drugs. This ultrarapid metabolizer phenotype and its impact on conventional …

The goal of this study is to develop an analytical tool to assess cytochrome P450 2D6
(CYP2D6) levels in the form of full-length transcripts. CYP2D6 RNA in test samples was …

In Japan, there is an apparent lack of development and stigma associated with mental
health treatment, including the use of antidepressants. Additionally, there is a large portion …

31 tás profil jellemzi. A béta-blokkolók döntően a máj citokróm P450 2d6 alegységén
metabolizálódnak (8, 9). A carvedilol, alfa-adrenoreceptor blokkoló tulajdonságával, míg a …