Mitochondria are key to energy conversion in virtually all eukaryotes. Intriguingly, despite
billions of years of evolution inside the eukaryote, mitochondria have retained their own …

The sexes show profound differences in responses to infection and the development of
autoimmunity. Dimorphisms in immune responses are ubiquitous across taxa, from …

The loss of appetite that typically accompanies infection or mere exposure to parasites is
traditionally considered a negative byproduct of infection, benefitting neither the host nor the …

Mitochondria are organelles that produce cellular energy in the form of ATP through
oxidative phosphorylation, and this primary function is conserved among many taxa …

Background Mitochondria participate in various cellular processes including energy
metabolism, apoptosis, autophagy, production of reactive oxygen species, stress responses …

Understanding why the response to infection varies between individuals remains one of the
major challenges in immunology and infection biology. A substantial proportion of this …

Mitochondrial and nuclear genomes have to coevolve to ensure the proper functioning of the
different mitochondrial complexes that are assembled from peptides encoded by both …

Senescence is manifested by an increase in molecular damage and a deterioration of
biological functions with age. In most organisms, body maintenance is traded-off with …

Even when successfully surviving an infection, a host often fails to eliminate a pathogen
completely and may sustain substantial pathogen burden for the remainder of its life. Using …

Mitochondria are vital organelles for life in eukaryotes, taking centre stage in the process of
cellular respiration. This process is regulated via a series of finely coordinated obligate …