Mass spectrometry–based proteomics has emerged as the leading method for detection,
quantification, and characterization of proteins. Nearly all proteomic workflows rely on …

Cancers are caused by accumulated DNA mutations. This recognition of the central role of
mutations in cancer and recent advances in next‐generation sequencing, has initiated the …

Cancer proteogenomics is an emerging field that aims to identify and quantify protein
sequence changes associated with the cancer genome. Besides being involved in cancer …

Background The nonrandom distribution of alleles of common genomic variants produces
haplotypes, which are fundamental in medical and population genetic studies …

In order to optimize sample preparation for shotgun proteomics, we compared four cysteine
alkylating agents: iodoacetamide, chloroacetamide, 4-vinylpyridine and methyl …

Genomic and proteomic data were integrated into the proteogenomic workflow to identify
coding genomic variants of Human Embryonic Kidney 293 (HEK‐293) cell line at the …

Proteogenomics is based on the use of customized genome or RNA sequencing databases
for interrogation of shotgun proteomics data in search for proteome‐level evidence of …

Mass spectrometric proteomic analysis at the sample preparation stage involves the artificial
reduction of disulfide bonds in proteins formed between cysteine residues. Such bonds …

Adenosine-to-inosine RNA editing is one of the most common types of RNA editing, a
posttranscriptional modification made by special enzymes. We present a proteomic study on …

An important aim of proteogenomics, which combines data of high throughput nucleic acid
and protein analysis, is to reliably identify single amino acid substitutions representing a …