Interactions between Borrelia burgdorferi and ticks

C Kurokawa, GE Lynn, JHF Pedra, U Pal… - Nature Reviews …, 2020 - nature.com
Borrelia burgdorferi is the causative agent of Lyme disease and is transmitted to vertebrate
hosts by Ixodes spp. ticks. The spirochaete relies heavily on its arthropod host for basic …

Lyme disease in humans

JD Radolf, K Strle, JE Lemieux, F Strle - Current issues in molecular …, 2021 - mdpi.com
Lyme disease (Lyme borreliosis) is a tick-borne, zoonosis of adults and children caused by
genospecies of the Borrelia burgdorferi sensu lato complex. The ailment, widespread …

Lyme disease pathogenesis

J Coburn, B Garcia, LT Hu, MW Jewett… - Current issues in …, 2021 - mdpi.com
Lyme disease Borrelia are obligately parasitic, tick-transmitted, invasive, persistent bacterial
pathogens that cause disease in humans and non-reservoir vertebrates primarily through …

Of ticks, mice and men: understanding the dual-host lifestyle of Lyme disease spirochaetes

JD Radolf, MJ Caimano, B Stevenson… - Nature reviews …, 2012 - nature.com
In little more than 30 years, Lyme disease, which is caused by the spirochaete Borrelia
burgdorferi, has risen from relative obscurity to become a global public health problem and a …

Interaction of the tick immune system with transmitted pathogens

O Hajdušek, R Šíma, N Ayllón, M Jalovecká… - Frontiers in cellular …, 2013 - frontiersin.org
Ticks are hematophagous arachnids transmitting a wide variety of pathogens including
viruses, bacteria, and protozoans to their vertebrate hosts. The tick vector competence has to …

Relapsing fevers: neglected tick-borne diseases

E Talagrand-Reboul, PH Boyer, S Bergström… - Frontiers in cellular …, 2018 - frontiersin.org
Relapsing fever still remains a neglected disease and little is known on its reservoir, tick
vector and physiopathology in the vertebrate host. The disease occurs in temperate as well …

Human pathogens utilize host extracellular matrix proteins laminin and collagen for adhesion and invasion of the host

B Singh, C Fleury, F Jalalvand… - FEMS microbiology …, 2012 - academic.oup.com
Laminin (Ln) and collagen are multifunctional glycoproteins that play an important role in
cellular morphogenesis, cell signalling, tissue repair and cell migration. These proteins are …

Correlation between plasmid content and infectivity in Borrelia burgdorferi

JE Purser, SJ Norris - … of the national academy of sciences, 2000 - National Acad Sciences
Infectivity-associated plasmids were identified in Borrelia burgdorferi B31 by using PCR to
detect each of the plasmids in a panel of 19 clonal isolates. The clones exhibited high-, low …

[HTML][HTML] A critical role for plasminogen in inflammation

SK Baker, S Strickland - Journal of Experimental Medicine, 2020 - rupress.org
Plasminogen and its active form, plasmin, have diverse functions related to the inflammatory
response in mammals. Due to these roles in inflammation, plasminogen has been …

Bacterial plasminogen activators and receptors

K Lähteenmäki, P Kuusela… - FEMS microbiology …, 2001 - academic.oup.com
Invasive bacterial pathogens intervene at various stages and by various mechanisms with
the mammalian plasminogen/plasmin system. A vast number of pathogens express plasmin …