Transthyretin: a multifaceted protein

M Vieira, MJ Saraiva - Biomolecular concepts, 2014 - degruyter.com
Transthyretin is a highly conserved homotetrameric protein, mainly synthetized by the liver
and the choroid plexus of brain. The carrier role of TTR is well-known; however, many other …

Transthyretin: from structural stability to osteoarticular and cardiovascular diseases

E Wieczorek, A Ożyhar - Cells, 2021 - mdpi.com
Transthyretin (TTR) is a tetrameric protein transporting hormones in the plasma and brain,
which has many other activities that have not been fully acknowledged. TTR is a positive …

The extracellular protein, transthyretin is an oxidative stress biomarker

M Sharma, S Khan, S Rahman, LR Singh - Frontiers in physiology, 2019 - frontiersin.org
The extracellular protein, transthyretin is responsible for the transport of thyroxin and retinol
binding protein complex to the various parts of the body. In addition to this transport function …

Sampling the N-terminal proteome of human blood

D Wildes, JA Wells - … of the National Academy of Sciences, 2010 - National Acad Sciences
The proteomes of blood plasma and serum represent a potential gold mine of biological and
diagnostic information, but challenges such as dynamic range of protein concentration have …

Transthyretin and the brain re-visited: is neuronal synthesis of transthyretin protective in Alzheimer's disease?

X Li, JN Buxbaum - Molecular neurodegeneration, 2011 - Springer
Since the mid-1990's a trickle of publications from scattered independent laboratories have
presented data suggesting that the systemic amyloid precursor transthyretin (TTR) could …

Transthyretin protects against A-beta peptide toxicity by proteolytic cleavage of the peptide: a mechanism sensitive to the Kunitz protease inhibitor

R Costa, F Ferreira-da-Silva, MJ Saraiva, I Cardoso - PloS one, 2008 - journals.plos.org
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by the deposition of
amyloid β-peptide (A-Beta) in the brain. Transthyretin (TTR) is a tetrameric protein of about …

The role of transthyretin in cell biology: impact on human pathophysiology

J Magalhães, J Eira, MA Liz - Cellular and Molecular Life Sciences, 2021 - Springer
Transthyretin (TTR) is an extracellular protein mainly produced in the liver and choroid
plexus, with a well-stablished role in the transport of thyroxin and retinol throughout the body …

Aboard transthyretin: From transport to cleavage

MA Liz, FM Mar, F Franquinho, MM Sousa - IUBMB life, 2010 - Wiley Online Library
Transthyretin (TTR) is a plasma and cerebrospinal fluid protein mainly recognized as the
transporter of thyroxine (T4) and retinol. Mutated TTR leads to familial amyloid …

Amyloid substance within stenotic aortic valves promotes mineralization

A Audet, N Côté, C Couture, Y Bossé… - …, 2012 - Wiley Online Library
Audet A, Côté N, Couture C, Bossé Y, Després J‐P, Pibarot P & Mathieu P (2012)
Histopathology 61, 610–619 Amyloid substance within stenotic aortic valves promotes …

Urinary proteomics based on capillary electrophoresis-coupled mass spectrometry in kidney disease: discovery and validation of biomarkers, and clinical application

H Mischak, C Delles, J Klein, JP Schanstra - Advances in chronic kidney …, 2010 - Elsevier
Use of capillary electrophoresis coupled to mass spectrometry (CE-MS) technology in
proteome analysis has increased, with a focus on the identification of biomarker peptides in …