An update on connexin gap junction and hemichannels in diabetic retinopathy

J González-Casanova, O Schmachtenberg… - International Journal of …, 2021 - mdpi.com
Diabetic retinopathy (DR) is one of the main causes of vision loss in the working age
population. It is characterized by a progressive deterioration of the retinal microvasculature …

Education interacts with genetic variants near GJD2, RBFOX1, LAMA2, KCNQ5 and LRRC4C to confer susceptibility to myopia

R Clark, A Pozarickij, PG Hysi, K Ohno-Matsui… - PLoS …, 2022 - journals.plos.org
Myopia most often develops during school age, with the highest incidence in countries with
intensive education systems. Interactions between genetic variants and educational …

Octodon degus: a natural model of multimorbidity for ageing research

L Cuenca-Bermejo, E Pizzichini… - Ageing Research …, 2020 - Elsevier
Integrating the multifactorial processes co-occurring in both physiological and pathological
human conditions still remains one of the main challenges in translational investigation …

Loss of Gap Junction Delta-2 (GJD2) gene orthologs leads to refractive error in zebrafish

WH Quint, KCD Tadema, E de Vrieze… - Communications …, 2021 - nature.com
Myopia is the most common developmental disorder of juvenile eyes, and it has become an
increasing cause of severe visual impairment. The GJD2 locus has been consistently …

Revisiting rodent models: Octodon degus as Alzheimer's disease model?

J Steffen, M Krohn, K Paarmann, C Schwitlick… - Acta neuropathologica …, 2016 - Springer
Alzheimer's disease primarily occurs as sporadic disease and is accompanied with vast
socio-economic problems. The mandatory basic research relies on robust and reliable …

Speed-selectivity in retinal ganglion cells is sharpened by broad spatial frequency, naturalistic stimuli

CR Ravello, LU Perrinet, MJ Escobar, AG Palacios - Scientific reports, 2019 - nature.com
Motion detection represents one of the critical tasks of the visual system and has motivated a
large body of research. However, it remains unclear precisely why the response of retinal …

Retinal aging in the diurnal Chilean rodent (Octodon degus): histological, ultrastructural and neurochemical alterations of the vertical information processing pathway

K Szabadfi, C Estrada, E Fernandez-Villalba… - Frontiers in cellular …, 2015 - frontiersin.org
The retina is sensitive to age-dependent degeneration. To find suitable animal models to
understand and map this process has particular importance. The degu (Octodon degus) is a …

[HTML][HTML] Differences in junction-associated gene expression changes in three rat models of diabetic retinopathy with similar neurovascular phenotype

M Kolibabka, M Dannehl, K Oezer, K Murillo… - Neurobiology of …, 2023 - Elsevier
Diabetic retinopathy, also defined as microvascular complication of diabetes mellitus, affects
the entire neurovascular unit with specific aberrations in every compartment …

Characterization of retinal functionality at different eccentricities in a diurnal rodent

MJ Escobar, C Reyes, R Herzog, J Araya… - Frontiers in cellular …, 2018 - frontiersin.org
Although the properties of the neurons of the visual system that process central and
peripheral regions of the visual field have been widely researched in the visual cortex and …

Dimensionality reduction on spatio-temporal maximum entropy models of spiking networks

R Herzog, MJ Escobar, R Cofre, AG Palacios… - bioRxiv, 2018 - biorxiv.org
Maximum entropy models (MEM) have been widely used in the last 10 years to characterize
the statistics of networks of spiking neurons. A major drawback of this approach is that the …