The C/EBP homologous protein (CHOP) transcription factor functions in endoplasmic reticulum stress-induced apoptosis and microbial infection

H Hu, M Tian, C Ding, S Yu - Frontiers in immunology, 2019 - frontiersin.org
Apoptosis is a form of cell death by which the body maintains the homeostasis of the internal
environment. Apoptosis is an initiative cell death process that is controlled by genes and is …

Oxidative stress: a suitable therapeutic target for optic nerve diseases?

F Buonfiglio, EW Böhm, N Pfeiffer, A Gericke - Antioxidants, 2023 - mdpi.com
Optic nerve disorders encompass a wide spectrum of conditions characterized by the loss of
retinal ganglion cells (RGCs) and subsequent degeneration of the optic nerve. The etiology …

Brain and blood biomarkers of tauopathy and neuronal injury in humans and rats with neurobehavioral syndromes following blast exposure

DL Dickstein, R De Gasperi, MA Gama Sosa… - Molecular …, 2021 - nature.com
Traumatic brain injury (TBI) is a risk factor for the later development of neurodegenerative
diseases that may have various underlying pathologies. Chronic traumatic encephalopathy …

Neuropathology in chronic traumatic encephalopathy: a systematic review of comparative post-mortem histology literature

HC Murray, C Osterman, P Bell, L Vinnell… - Acta Neuropathologica …, 2022 - Springer
Chronic traumatic encephalopathy (CTE) is a neurodegenerative disease associated with
repetitive head trauma and is characterised by the perivascular accumulation of …

Considerations for experimental animal models of concussion, traumatic brain injury, and chronic traumatic encephalopathy—these matters matter

MW Wojnarowicz, AM Fisher, O Minaeva… - Frontiers in …, 2017 - frontiersin.org
Animal models of concussion, traumatic brain injury (TBI), and chronic traumatic
encephalopathy (CTE) are widely available and routinely deployed in laboratories around …

Oxidative stress in the brain and retina after traumatic injury

AK Ryan, W Rich, MA Reilly - Frontiers in neuroscience, 2023 - frontiersin.org
The brain and the retina share many physiological similarities, which allows the retina to
serve as a model of CNS disease and disorder. In instances of trauma, the eye can even …

Salubrinal reduces oxidative stress, neuroinflammation and impulsive-like behavior in a rodent model of traumatic brain injury

AF Logsdon, BP Lucke-Wold, L Nguyen… - Brain research, 2016 - Elsevier
Traumatic brain injury (TBI) is the leading cause of trauma related morbidity in the
developed world. TBI has been shown to trigger secondary injury cascades including …

Chronic traumatic encephalopathy-like abnormalities in a routine neuropathology service

S Noy, S Krawitz, MR Del Bigio - Journal of Neuropathology & …, 2016 - academic.oup.com
Chronic traumatic encephalopathy (CTE) has been described mainly in professional
athletes and military personnel and is characterized by deposition of hyperphosphorylated …

Chronic traumatic encephalopathy-integration of canonical traumatic brain injury secondary injury mechanisms with tau pathology

JR Kulbe, ED Hall - Progress in neurobiology, 2017 - Elsevier
In recent years, a new neurodegenerative tauopathy labeled Chronic Traumatic
Encephalopathy (CTE), has been identified that is believed to be primarily a sequela of …

Endoplasmic reticulum stress and the unfolded protein response: emerging regulators in progression of traumatic brain injury

Y Yang, D Lu, M Wang, G Liu, Y Feng, Y Ren… - Cell Death & …, 2024 - nature.com
Traumatic brain injury (TBI) is a common trauma with high mortality and disability rates
worldwide. However, the current management of this disease is still unsatisfactory …