Malaria parasite liver infection and exoerythrocytic biology

AM Vaughan, SHI Kappe - Cold Spring …, 2017 - perspectivesinmedicine.cshlp.org
In their infection cycle, malaria parasites undergo replication and population expansions
within the vertebrate host and the mosquito vector. Host infection initiates with sporozoite …

Immune escape strategies of malaria parasites

PS Gomes, J Bhardwaj, J Rivera-Correa… - Frontiers in …, 2016 - frontiersin.org
Malaria is one of the most life-threatening infectious diseases worldwide. Immunity to
malaria is slow and short-lived despite the repeated parasite exposure in endemic areas …

Cross-kingdom lipid transfer in arbuscular mycorrhiza symbiosis and beyond

A Keymer, C Gutjahr - current opinion in plant biology, 2018 - Elsevier
Highlights•Arbuscular mycorrhiza fungi are likely fatty acid auxotrophs.•Plants maintain an
arbuscular mycorrhiza (AM)-specific lipid biosynthesis pathway.•Independent experimental …

Lipid hijacking: a unifying theme in vector-borne diseases

AJ O'Neal, LR Butler, A Rolandelli, SD Gilk, JHF Pedra - Elife, 2020 - elifesciences.org
Vector-borne illnesses comprise a significant portion of human maladies, representing 17%
of global infections. Transmission of vector-borne pathogens to mammals primarily occurs …

Outer membrane vesicles from a mosquito commensal mediate targeted killing of Plasmodium parasites via the phosphatidylcholine scavenging pathway

H Gao, Y Jiang, L Wang, G Wang, W Hu… - Nature …, 2023 - nature.com
The gut microbiota is a crucial modulator of Plasmodium infection in mosquitoes, including
the production of anti-Plasmodium effector proteins. But how the commensal-derived …

Multiple blood feeding in mosquitoes shortens the Plasmodium falciparum incubation period and increases malaria transmission potential

WR Shaw, IE Holmdahl, MA Itoe, K Werling… - PLoS …, 2020 - journals.plos.org
Many mosquito species, including the major malaria vector Anopheles gambiae, naturally
undergo multiple reproductive cycles of blood feeding, egg development and egg laying in …

Plasmodium UIS3 sequesters host LC3 to avoid elimination by autophagy in hepatocytes

E Real, L Rodrigues, GG Cabal, FJ Enguita… - Nature …, 2018 - nature.com
The causative agent of malaria, Plasmodium, replicates inside a membrane-bound
parasitophorous vacuole (PV), which shields this intracellular parasite from the cytosol of the …

[HTML][HTML] Steroid hormone function controls non-competitive Plasmodium development in Anopheles

K Werling, WR Shaw, MA Itoe, KA Westervelt… - Cell, 2019 - cell.com
Transmission of malaria parasites occurs when a female Anopheles mosquito feeds on an
infected host to acquire nutrients for egg development. How parasites are affected by …

Parasite sensing of host nutrients and environmental cues

V Zuzarte-Luís, MM Mota - Cell Host & Microbe, 2018 - cell.com
Parasites undergo complex life cycles that comprise a wide variety of cellular differentiation
events in different host compartments and transmission across multiple hosts. As parasites …

Host-directed therapy, an untapped opportunity for antimalarial intervention

L Wei, J Adderley, D Leroy, DH Drewry, DW Wilson… - Cell Reports …, 2021 - cell.com
Host-directed therapy (HDT) is gaining traction as a strategy to combat infectious diseases
caused by viruses and intracellular bacteria, but its implementation in the context of parasitic …