Bone defects cause significant socio-economic costs worldwide, while the clinical “gold
standard” of bone repair, the autologous bone graft, has limitations including limited graft …

Human pluripotent stem cells (PSCs) are a leading candidate for cell-based therapies
because of their capacity for unlimited self renewal and pluripotent differentiation. These …

Retinal neurodegenerative diseases like age-related macular degeneration, glaucoma,
diabetic retinopathy and retinitis pigmentosa each have a different etiology and …

After years of incremental progress, several recent studies have succeeded in deriving
disease-relevant cell types from human pluripotent stem cell (hPSC) sources. The prospect …

The breakthrough of reprogramming human somatic cells was achieved in 2006 by the work
of Yamanaka and Takahashi. From this point, fibroblasts are the most commonly used …

Mesenchymal stem cells (MSCs) have been the subject of many studies in recent years,
ranging from basic science that looks into MSCs properties to studies that aim for developing …

Cell therapies aim to repair the mechanisms underlying disease initiation and progression,
achieved through trophic effect or by cell replacement. Multiple cell types can be utilized in …

Hundreds of transcription factors (TFs) are expressed in each cell type, but cell identity can
be induced through the activity of just a small number of core TFs. Systematic identification …

Tyrosine-type site-specific recombinases (T-SSRs) have opened new avenues for the
predictable modification of genomes as they enable precise genome editing in heterologous …

Aim: To provide a comprehensive analysis of clinical trials (CTs) listed in worldwide
registries involving new applications for stem cell-based treatments and account for the role …