Immunosuppression is a hallmark of pancreatic ductal adenocarcinoma (PDAC),
contributing to early metastasis and poor patient survival. Compared to the localized tumors …

This article focuses on the role of Rho family GTPases, particularly Rac1 and Rac1b in TGF‐
β‐induced epithelial‐mesenchymal transition (EMT) and EMT‐associated responses such …

TGF-β signaling is involved in pancreatic ductal adenocarcinoma (PDAC) tumorigenesis,
representing one of the four major pathways genetically altered in 100% of PDAC cases …

The small GTPase Rac1 has been implicated in a variety of dynamic cell biological
processes, including cell proliferation, cell survival, cell-cell contacts, epithelial …

Breast, lung, and pancreatic cancers collectively represent one third of all diagnosed tumors
and are responsible for almost 40% of overall cancer mortality. Despite improvements in …

The multi-functional cytokine transforming growth factor-β1 (TGF-β1) has growth inhibitory
and anti-inflammatory roles during homeostasis and the early stages of cancer. Aberrant …

This article focusses on the role of TGF-β and its signaling crosstalk with the RHO family
GTPases RAC1 and RAC1b in the progression of breast and pancreatic carcinoma. The …

RAC1B is an alternatively spliced isoform of the monomeric GTPase RAC1. It differs from
RAC1 by a 19 amino acid in frame insertion, termed exon 3b, resulting in an accelerated …

Pancreatic ductal adenocarcinoma (PDAC), which accounts for 96% of all pancreatic cancer
cases, is characterized by rapid progression, invasion and metastasis. Transforming growth …

Background Epithelial–mesenchymal transition (EMT) is the major pathophysiological
process in lung fibrosis observed in chronic obstructive pulmonary disease (COPD) and …