Molecular mechanisms underlying vertebrate adaptive evolution: a systematic review

F Martínez Sosa, M Pilot - Genes, 2023 - mdpi.com
Adaptive evolution is a process in which variation that confers an evolutionary advantage in
a specific environmental context arises and is propagated through a population. When …

Proteomic stratification of prognosis and treatment options for small cell lung cancer

Z Huo, Y Duan, D Zhan, X Xu, N Zheng… - Genomics …, 2024 - academic.oup.com
Small cell lung cancer (SCLC) is a highly malignant and heterogeneous cancer with limited
therapeutic options and prognosis prediction models. Here, we analyzed formalin-fixed …

Coevolution between MHC class I and antigen-processing genes in salamanders

G Palomar, K Dudek, M Migalska… - Molecular Biology …, 2021 - academic.oup.com
Proteins encoded by antigen-processing genes (APGs) provide major histocompatibility
complex (MHC) class I (MHC-I) with antigenic peptides. In mammals, polymorphic multigenic …

MHC Architecture in Amphibians—Ancestral Reconstruction, Gene Rearrangements, and Duplication Patterns

K He, W Babik, M Majda, P Minias - Genome Biology and …, 2023 - academic.oup.com
The hypervariable major histocompatibility complex (MHC) is a crucial component of
vertebrate adaptive immunity, but large-scale studies on MHC macroevolution in nonmodel …

Holostean genomes reveal evolutionary novelty in the vertebrate immunoproteasome that have implications for MHCI function

AV Barker, KB Carlson, DJ Wcisel… - bioRxiv, 2024 - biorxiv.org
Holosteans (gars and bowfins) have emerged as valuable models for understanding early
vertebrate evolution, offering insights into diverse topics ranging from genomic architecture …