Post-translational modifications of histones by protein methyltransferases (PMTs) and
histone demethylases (KDMs) play an important role in the regulation of gene expression …

S-Adenosyl-L-methionine (SAM) is a sulfonium molecule with a structural hybrid of
methionine and adenosine. As the second largest cofactor in the human body, its major …

Selective manipulation of the epitranscriptome could be beneficial for the treatment of
cancer and also broaden the understanding of epigenetic inheritance. Inhibitors of the tRNA …

Identification of structurally novel inhibitors of lysine methyltransferase G9a has been a
subject of intense research in cancer epigenetics. Starting with the high-throughput …

G9a-like protein (GLP) and G9a are highly homologous protein lysine methyltransferases
(PKMTs) sharing approximately 80% sequence identity in their catalytic domains. GLP and …

Protein lysine methyltransferases constitute a large family of epigenetic writers that catalyse
the transfer of a methyl group from the cofactor S-adenosyl-L-methionine to histone-and non …

The parasitic protozoan Trypanosoma brucei causes Human African Trypanosomiasis and
Nagana in other mammals. These diseases present a major socio-economic burden to large …

Since the discovery of compound BIX01294 over 10 years ago, only a very limited number of
nonquinazoline inhibitors of H3K9-specific methyltransferases G9a and G9a-like protein …

Protein lysine methyltransferases G9a and GLP, which catalyze mono-and di-methylation of
histone H3K9 and nonhistone proteins, play important roles in diverse cellular processes …

Methylation at histone 3, lysine 36 (H3K36) is a conserved epigenetic mark regulating gene
transcription, alternative splicing and DNA repair. Genes encoding H3K36 …