Malformations of cortical development are a group of rare disorders commonly manifesting
with developmental delay, cerebral palsy or seizures. The neurological outcome is …

Folding of the cerebral cortex is a fundamental milestone of mammalian brain evolution and
is associated with dramatic increases in size and complexity. New animal models, genetic …

Malformations of cortical development (MCDs) are neurodevelopmental disorders that result
from abnormal development of the cerebral cortex in utero. MCDs place a substantial …

INTRODUCTION The cerebral cortex, or neocortex, is critical to key mammalian skills such
as language, sociability, and sensorimotor control. This structure consists of dozens of …

Lissencephaly ('smooth brain') is a severe brain disease associated with numerous
symptoms, including cognitive impairment, and shortened lifespan. The main causative …

The development of the human cerebral cortex is a complex and dynamic process, in which
neural stem cell proliferation, neuronal migration, and post-migratory neuronal organization …

Mutations in the cytoplasmic dynein 1 heavy chain gene (DYNC1H1) have been identified in
rare neuromuscular (NMD) and neurodevelopmental (NDD) disorders such as spinal …

Lissencephaly represents a spectrum of rare malformations of cortical development
including agyria, pachygyria and subcortical band heterotopia. The progress in molecular …

Cell polarity refers to the asymmetric distribution of signaling molecules, cellular organelles,
and cytoskeleton in a cell. Neural progenitors and neurons are highly polarized cells in …

Reelin (RELN) is a secreted glycoprotein essential for cerebral cortex development. In
humans, recessive RELN variants cause cortical and cerebellar malformations, while …