Exciting new discoveries have transformed the view of the lysosome from a static organelle
dedicated to the disposal and recycling of cellular waste to a highly dynamic structure that …

The active transport of organelles and other cargos along the axon is required to maintain
neuronal health and function, but we are just beginning to understand the complex …

The majority of therapies that target individual proteins rely on specific activity-modulating
interactions with the target protein—for example, enzyme inhibition or ligand blocking …

Removal of senescent cells (senolysis) has been proposed to be beneficial for improving
age-associated pathologies, but the molecular pathways for such senolytic activity have not …

Lysosomes require an acidic lumen between pH 4.5 and 5.0 for effective digestion of
macromolecules. This pH optimum is maintained by proton influx produced by the V-ATPase …

Lysosomes are membrane-bound organelles with roles in processes involved in degrading
and recycling cellular waste, cellular signalling and energy metabolism. Defects in genes …

Wnt/β-catenin signaling is implicated in many physiological processes, including
development, tissue homeostasis, and tissue regeneration. In human cancers, Wnt/β-catenin …

Lysosomes are membrane‐enclosed organelles that mediate the intracellular degradation
of macromolecules. They play an essential role in calcium regulation and have emerged as …

Lysosomes are catabolic organelles that govern numerous cellular processes, including
macromolecule degradation, nutrient signalling and ion homeostasis. Aberrant changes in …

Hyperactive TLR7 signaling has long been appreciated as driver of autoimmune disease in
mouse models. Recently, gain-of-function mutations in TLR7 were identified as a monogenic …