A comprehensive review on microbial l‐asparaginase: Bioprocessing, characterization, and industrial applications
S Chand, RV Mahajan, JP Prasad… - Biotechnology and …, 2020 - Wiley Online Library
Abstract l‐Asparaginase (EC 3.5. 1.1.) is a vital enzyme that hydrolyzes l‐asparagine to l‐
aspartic acid and ammonia. This property of l‐asparaginase inhibits the protein synthesis in …
aspartic acid and ammonia. This property of l‐asparaginase inhibits the protein synthesis in …
L-asparaginase as a critical component to combat Acute Lymphoblastic Leukaemia (ALL): A novel approach to target ALL
L-asparaginase, an anti-leukaemic drug that has been approved for clinical use for many
years in the treatment of childhood Acute Lymphoblastic Leukaemia (ALL), is obtained from …
years in the treatment of childhood Acute Lymphoblastic Leukaemia (ALL), is obtained from …
Cloning, Expression, and Characterization of l-Asparaginase from a Newly Isolated Bacillus subtilis B11–06
M Jia, M Xu, B He, Z Rao - Journal of agricultural and food …, 2013 - ACS Publications
This study focused on the cloning, overexpression, and characterization of the gene
encoding l-asparaginase (ansZ) from a nonpathogenic strain of Bacillus subtilis B11–06 …
encoding l-asparaginase (ansZ) from a nonpathogenic strain of Bacillus subtilis B11–06 …
Biochemical Characterization of a Novel l-Asparaginase with Low Glutaminase Activity from Rhizomucor miehei and Its Application in Food Safety and Leukemia …
L Huang, Y Liu, Y Sun, Q Yan… - Applied and environmental …, 2014 - Am Soc Microbiol
ABSTRACT A novel fungal gene encoding the Rhizomucor miehei l-asparaginase
(RmAsnase) was cloned and expressed in Escherichia coli. Its deduced amino acid …
(RmAsnase) was cloned and expressed in Escherichia coli. Its deduced amino acid …
Identification of a thermostable fungal lytic polysaccharide monooxygenase and evaluation of its effect on lignocellulosic degradation
R Zhang, Y Liu, Y Zhang, D Feng, S Hou… - Applied microbiology …, 2019 - Springer
Abstract Auxiliary activity family 9 (AA9) lytic polysaccharide monooxygenases (LPMOs)
show significant synergism with cellulase in cellulose degradation. In recent years, there …
show significant synergism with cellulase in cellulose degradation. In recent years, there …
Refolding and purification of recombinant L-asparaginase from inclusion bodies of E. coli into active tetrameric protein
A tetrameric protein of therapeutic importance, Escherichia coli L-asparaginase-II was
expressed in Escherichia coli as inclusion bodies (IBs). Asparaginase IBs were solubilized …
expressed in Escherichia coli as inclusion bodies (IBs). Asparaginase IBs were solubilized …
Cloning and characterization of Halomonas elongata L-asparaginase, a promising chemotherapeutic agent
L-asparaginase has been used in the treatment of patients with acute lymphoblastic
leukemia (ALL) for more than 30 years. Rapid clearance of the enzyme from blood stream …
leukemia (ALL) for more than 30 years. Rapid clearance of the enzyme from blood stream …
L-Asparaginase activity analysis, ansZ gene identification and anticancer activity of a new Bacillus subtilis isolated from sponges of the Red Sea
This study describes the isolation of various marine bacteriafrom sponges collected from the
Red Sea (Saudi Arabia) andL-asparaginase (anti-cancer enzyme) production from …
Red Sea (Saudi Arabia) andL-asparaginase (anti-cancer enzyme) production from …
Cloning, expression and characterization of l-asparaginase from Pseudomonas fluorescens for large scale production in E. coli BL21
V Kishore, KP Nishita, HK Manonmani - 3 Biotech, 2015 - Springer
Abstract l-Asparaginase (EC 3.5. 1.1) is used as an anti-neoplastic drug in the treatment of
acute lymphoblastic leukemia. l-Asparaginase from Pseudomonas fluorescens was cloned …
acute lymphoblastic leukemia. l-Asparaginase from Pseudomonas fluorescens was cloned …
Genetic and metabolic engineering approaches for the production and delivery of L-asparaginases: An overview
J Vidya, S Sajitha, MV Ushasree, R Sindhu… - Bioresource …, 2017 - Elsevier
L-asparaginase is one of the protein drugs for countering leukemia and lymphoma. A major
challenge in the therapeutic potential of the enzyme is its immunogenicity, low-plasma half …
challenge in the therapeutic potential of the enzyme is its immunogenicity, low-plasma half …