Cancer is one of the leading causes of death in both men and women worldwide. One of the
main changes associated with cancer progression, metastasis, recurrence, and …

Abstract Treatment of cancers has always been a challenge for physicians. Typically,
several groups of anti-cancer medications are needed for effective management of an …

Cyclin-dependent kinases (CDK) control the cell cycle and play a crucial role in
oncogenesis. Pharmacologic inhibition of CDK has contributed to the recent clinical …

Simple Summary Inhibition of cyclin-dependent kinase 9 (CDK9) can impact multiple
survival pathways in cancers and may be a promising therapeutic approach for …

Background Novel cancer immunotherapy seeks to harness the body's own immune system
and tip the balance in favour of antitumour activity. The intracellular enzyme indoleamine 2 …

Background Despite aggressive treatment, more than 90% of glioblastoma (GBM) patients
experience recurrences. GBM response to therapy is currently assessed by imaging …

Cancer-associated fibroblasts (CAFs) are involved in critical aspects of head and neck
squamous cell carcinoma (HNSCC) pathogenesis, such as the formation of a tumor …

Malignancies are unquestionably a significant public health problem. Their effective
treatment is still a big challenge for modern medicine. Tumors have developed a wide range …

Background Tryptophan 2, 3-dioxygenase (TDO2) is one of the emerging immune
checkpoints. Meanwhile, TDO2 is also a key enzyme in the tryptophan (Trp)–kynurenine …

The kynurenine pathway receives increasing attention due to its involvement in central
nervous system pathologies, ia neurodegenerative and psychiatric disorders, but also due to …