Human pluripotent stem-cell-derived organoids are models for human development and
disease. We report a modified human kidney organoid system that generates thousands of …

The adult mammalian kidney is a poorly regenerating organ that lacks the stem cells that
could replenish functional homeostasis similarly to, eg, skin or the hematopoietic system …

Over eighty million people in the United States have cardiovascular disease that can affect
the heart causing myocardial infarction; the carotid arteries causing stroke; and the lower …

Primary cilia are polarized organelles that allow detection of extracellular signals such as
Hedgehog (Hh). How the cytoskeleton supporting the cilium generates and maintains a …

Formation and homeostasis of the vascular system requires several coordinated cellular
functions, but their precise interplay during development and their relative importance for …

It is unclear whether the establishment of apical–basal cell polarity during the generation of
epithelial lumens requires molecules acting at the plasma membrane/actin interface. Here …

Polarization along an apico-basolateral axis is a hallmark of epithelial cells and is essential
for their selective barrier and transporter functions, as well as for their ability to provide …

Bardet–Biedl syndrome (BBS) is a rare pleiotropic inherited disorder known as a ciliopathy.
Kidney disease is a cardinal clinical feature; however, it is one of the less investigated traits …

Rho proteins operate as key regulators of the cytoskeleton, cell morphology and trafficking.
Acting as molecular switches, the function of Rho GTPases is determined by guanosine …

Advances in genome science in the last 20 years have led to the discovery of over 50 single
gene causes and genetic risk loci for steroid resistant nephrotic syndrome (SRNS). Despite …