Risks of organic UV filters: a review of environmental and human health concern studies

Y Huang, JCF Law, TK Lam, KSY Leung - Science of The Total …, 2021 - Elsevier
Organic UV filters are compounds that absorb UV irradiation by their highly conjugated
structure. With the developing consciousness over the last century of the skin damage UV …

Sperm migration, selection, survival, and fertilizing ability in the mammalian oviduct

C Mahé, AM Zlotkowska, K Reynaud… - Biology of …, 2021 - academic.oup.com
In vitro fertilization (IVF) gives rise to embryos in a number of mammalian species and is
currently widely used for assisted reproduction in humans and for genetic purposes in cattle …

Human fertilization in vivo and in vitro requires the CatSper channel to initiate sperm hyperactivation

S Young, C Schiffer, A Wagner, J Patz… - The Journal of …, 2024 - Am Soc Clin Investig
The infertility of many couples rests on an enigmatic dysfunction of the man's sperm. To gain
insight into the underlying pathomechanisms, we assessed the function of the sperm …

[HTML][HTML] CatSper: The complex main gate of calcium entry in mammalian spermatozoa

R Rahban, S Nef - Molecular and cellular endocrinology, 2020 - Elsevier
Abstract Calcium ions (Ca 2+) are involved in nearly every aspect of cellular life. They are
one of the most abundant elements in mammals and play a vital role in physiological and …

CatSper calcium channels: 20 years on

JY Hwang, JJ Chung - Physiology, 2023 - journals.physiology.org
The flagellar-specific Ca2+ channel CatSper is the predominant Ca2+ entry site in
mammalian sperm. CatSper-mediated Ca2+ signaling affects nearly every event that …

Monitoring of pollutants content in bottled and tap drinking water in Italy

G Russo, S Laneri, R Di Lorenzo, I Neri, I Dini… - Molecules, 2022 - mdpi.com
The concentration levels of thirteen organic pollutants and selected heavy metals were
investigated in 40 plastics bottled and tap water samples. Some of the selected …

Rotational motion and rheotaxis of human sperm do not require functional CatSper channels and transmembrane Ca2+ signaling

C Schiffer, S Rieger, C Brenker, S Young… - The EMBO …, 2020 - embopress.org
Navigation of sperm in fluid flow, called rheotaxis, provides long‐range guidance in the
mammalian oviduct. The rotation of sperm around their longitudinal axis (rolling) promotes …

[HTML][HTML] In vitro investigation of endocrine disrupting effects of pesticides on Ca2+-signaling in human sperm cells through actions on the sperm-specific and steroid …

MR Birch, M Johansen, NE Skakkebæk… - Environment …, 2022 - Elsevier
Background Ca 2+-signaling controls sperm cell functions necessary for successful
fertilization. Multiple endocrine disrupting chemicals have been found to interfere with …

The Ca2+ channel CatSper is not activated by cAMP/PKA signaling but directly affected by chemicals used to probe the action of cAMP and PKA

T Wang, S Young, H Krenz, F Tüttelmann… - Journal of Biological …, 2020 - ASBMB
The sperm-specific Ca 2+ channel CatSper (cation channel of sperm) controls the influx of
Ca 2+ into the flagellum and, thereby, the swimming behavior of sperm. A hallmark of human …

Discovery and characterization of multiple classes of human CatSper blockers

EJ Carlson, R Francis, Y Liu, P Li, M Lyon… - …, 2022 - Wiley Online Library
The cation channel of sperm (CatSper) is a validated target for nonhormonal male
contraception, but it lacks selective blockers, hindering studies to establish its role in both …