Nonribosomal peptide synthesis—principles and prospects
RD Süssmuth, A Mainz - Angewandte Chemie International …, 2017 - Wiley Online Library
Nonribosomal peptide synthetases (NRPSs) are large multienzyme machineries that
assemble numerous peptides with large structural and functional diversity. These peptides …
assemble numerous peptides with large structural and functional diversity. These peptides …
Evolution and diversity of assembly-line polyketide synthases: Focus review
Assembly-line polyketide synthases (PKSs) are among the most complex protein
machineries known in nature, responsible for the biosynthesis of numerous compounds …
machineries known in nature, responsible for the biosynthesis of numerous compounds …
An environmental bacterial taxon with a large and distinct metabolic repertoire
Cultivated bacteria such as actinomycetes are a highly useful source of biomedically
important natural products. However, such 'talented'producers represent only a minute …
important natural products. However, such 'talented'producers represent only a minute …
Recent advances in engineering nonribosomal peptide assembly lines
Covering: up to July 2015 Nonribosomal peptides are amongst the most widespread and
structurally diverse secondary metabolites in nature with many possessing bioactivity that …
structurally diverse secondary metabolites in nature with many possessing bioactivity that …
Synthetic biology and metabolic engineering of actinomycetes for natural product discovery
Actinomycetes are one of the most valuable sources of natural products with industrial and
medicinal importance. After more than half a century of exploitation, it has become …
medicinal importance. After more than half a century of exploitation, it has become …
Gene editing enables rapid engineering of complex antibiotic assembly lines
Re-engineering biosynthetic assembly lines, including nonribosomal peptide synthetases
(NRPS) and related megasynthase enzymes, is a powerful route to new antibiotics and other …
(NRPS) and related megasynthase enzymes, is a powerful route to new antibiotics and other …
Efficient rational modification of non-ribosomal peptides by adenylation domain substitution
Non-ribosomal peptide synthetase (NRPS) enzymes form modular assembly-lines, wherein
each module governs the incorporation of a specific monomer into a short peptide product …
each module governs the incorporation of a specific monomer into a short peptide product …
Bacterial terpene biosynthesis: challenges and opportunities for pathway engineering
Terpenoids are the largest and structurally most diverse class of natural products. They
possess potent and specific biological activity in multiple assays and against diseases …
possess potent and specific biological activity in multiple assays and against diseases …
[HTML][HTML] Complex peptide natural products: biosynthetic principles, challenges and opportunities for pathway engineering
SL Wenski, S Thiengmag, EJN Helfrich - Synthetic and systems …, 2022 - Elsevier
Complex peptide natural products exhibit diverse biological functions and a wide range of
physico-chemical properties. As a result, many peptides have entered the clinics for various …
physico-chemical properties. As a result, many peptides have entered the clinics for various …
The landscape of recombination events that create nonribosomal peptide diversity
Nonribosomal peptides (NRP) are crucial molecular mediators in microbial ecology and
provide indispensable drugs. Nevertheless, the evolution of the flexible biosynthetic …
provide indispensable drugs. Nevertheless, the evolution of the flexible biosynthetic …