Abstract The Klotho proteins, αKlotho and βKlotho, are essential components of endocrine
fibroblast growth factor (FGF) receptor complexes, as they are required for the high-affinity …

Advancing age promotes cardiovascular disease (CVD), the leading cause of death in the
United States and many developed nations. Two major age-related arterial phenotypes …

Loss of Klotho, an anti-aging protein, plays a critical role in the pathogenesis of chronic
kidney diseases. As Klotho is a large transmembrane protein, it is challenging to harness it …

Abstract Introduction The protein Klotho (KL) was first discovered in KL-deficient mice, which
developed a syndrome similar to premature aging in humans. Since then, KL has been …

Individuals age> 65 years old are the fastest expanding population demographic throughout
the developed world. Consequently, more aged patients than before are receiving …

The discovery of the Klotho (KL) gene, which was originally identified as a putative aging-
suppressor gene, has generated tremendous interest and has advanced understanding of …

Alzheimer's disease is the most common neurodegenerative disorder that can cause
dementia in elderly over 60 years of age. One of the disease hallmarks is oxidative stress …

A defect in Klotho gene expression in mice accelerates the degeneration of multiple age-
sensitive traits. Here, we show that overexpression of Klotho in mice extends life span …

Fibrosis is a pathological process characterized by infiltration and proliferation of
mesenchymal cells in interstitial space. A substantial portion of these cells is derived from …

A wealth of observational studies show that low testosterone is associated with insulin
resistance and with an increased risk of diabetes and the metabolic syndrome. Experimental …